Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.
Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.
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DOI：
10.1016/j.ijwd.2017.01.006
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发表时间：
2017-03-01
影响因子：
--
通讯作者：
Shinkai, K
中科院分区：
文献类型：
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作者：
Afifi, L;Saeed, L;Shinkai, K
背景：种族、菲茨帕特里克皮肤类型（FST）和多囊卵巢综合征（PCOS）患者多毛症之间复杂的相互作用尚不清楚。目的：在这项横断面、回顾性分析中，我们在美国多囊卵巢综合征（PCOS）患者的不同队列中，使用临床评估的部位特异性和总改良Ferriman-Gallwey （mFG）视觉评分来检查多毛症的患病率、严重程度和分布。方法：根据患者报告的FST评分和种族进行独立分析。结果：在这个多囊卵巢综合征队列中，发现多毛症和种族之间存在相关性，在西班牙裔、中东、非洲裔美国人和南亚患者中，多毛症的患病率和mFG总分最高。多毛症和FST之间的正相关也被观察到，在FST较高的患者组中，多毛症的患病率增加。多毛症的解剖分布在不同种族之间也有显著的趋势。非裔美国患者的面部mFG评分较高，而中东患者的躯干和四肢区域mFG评分较高。躯干多毛症也与较高的FSTs有关。结论：种族和FST可能是多囊卵巢综合征女性多毛症定量和定性表现的重要变量，在任何怀疑患有多囊卵巢综合征的患者的诊断评估中都应考虑到这一点。先前发表的研究在同质队列中对种族、FST和多毛症进行了研究，这些研究限制了比较和普遍性，但本研究的优势在于其对单个大型多样化PCOS队列的详细分析。需要经过验证的研究来确定多囊卵巢综合征人群中多毛症的临床标准是否应该根据种族和FST进行调整，特别是在不同的队列和混合血统的患者中。
BACKGROUND: The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood.OBJECTIVE: In this cross-sectional, retrospective analysis, we examined the prevalence, severity, and distribution of hirsutism with clinician-rated site-specific and total modified Ferriman-Gallwey (mFG) visual scoring in a diverse cohort of American patients with PCOS.METHODS: Independent analyses were conducted on the basis of patient-reported FST ratings and ethnicity.RESULTS: In this PCOS cohort, a correlation was found between hirsutism and ethnicity and the highest prevalence of hirsutism and total mFG scores was observed in Hispanic, Middle Eastern, African American, and South Asian patients. A positive correlation between hirsutism and FST was also observed with an increasing prevalence of hirsutism in the group of patients with higher FSTs. Significant trends in the anatomic distribution of hirsutism were observed between ethnic groups as well. A higher facial mFG score was found in African American patients but higher mFG scores in the truncal and extremity regions were observed in Middle Eastern patients. Truncal hirsutism was also associated with higher FSTs.CONCLUSIONS: Ethnicity and FST may be important variables in both the quantitative and qualitative presentations of hirsutism in women with PCOS and should be considered in the diagnostic evaluation of any patient who is suspected of having the condition. Previously published studies that examined ethnicity, FST, and hirsutism in homogeneous cohorts limited comparison and generalizability but the strength of this study lies in its detailed analysis within a single large and diverse PCOS cohort. Validated studies are needed to determine whether clinical criteria for hirsutism should be adjusted for ethnicity and FST in the PCOS population and particularly within diverse cohorts and patients of mixed ancestry.