Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes
Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes
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DOI：
10.1021/jo100254g
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发表时间：
2010-05-07
影响因子：
3.6
通讯作者：
Hong, Soon Hyeok
中科院分区：
文献类型：
--
作者：
Muthaiah, Senthilkumar;Ghosh, Subhash Chandra;Hong, Soon Hyeok
以易得的RuH(2)(PPh(3))(4)、N-杂环卡宾(NHC)前体NaH和乙腈为原料，开发了一种原位生成催化剂。该催化剂对醇、醛与胺直接合成酰胺反应具有较高的活性。当醇和醛的混合物与胺反应时，两个相应的酰胺都以很好的产率得到。均相Ru(0)配合物如eta(4)-1，5-cyclooctadiene)(eta(6)-1，3，5-cyclooetatriene)-ruthenium[Ru(Cod)(Cot)]和Ru(3)(CO)(12)在原位生成的NHC配体的帮助下，也对醇或醛的酰胺化反应具有活性。
An in situ generated catalyst from readily available RuH(2)(PPh(3))(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as eta(4)-1,5-cyclooctadiene)(eta(6)-1,3,5-cyclooetatriene)-ruthenium [Ru(cod)(cot)] and Ru(3)(CO)(12) were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.