The Australian and New Zealand Intergenerational Cohort Consortium: a study protocol for investigating mental health and well-being across generations
The Australian and New Zealand Intergenerational Cohort Consortium: a study protocol for investigating mental health and well-being across generations
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DOI：
10.1332/175795920x15792720930280
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发表时间：
2020-04-01
影响因子：
0.9
通讯作者：
Patton, George C.
中科院分区：
文献类型：
--
作者：
Olsson, Craig A.;Spry, Elizabeth;Patton, George C.
澳大利亚-新西兰代际队列联盟（ANZ-ICC）汇集了澳大利亚和新西兰三项持续时间最长的代际队列研究，以研究孕前父母生活史（从婴儿到父母）预测下一代早期健康和发展的程度。目标有三个：（1）描述从一代人到下一代人加强情绪健康和幸福的优势途径，（2）描述使情绪和行为问题的循环持续下去的劣势途径，以及（3）确定能够打破代际循环的可改变因素。维多利亚州代际健康队列研究自1992年以来，对1，943名澳大利亚年轻人从青春期到成年进行了10次随访，自2006年以来，对1，030名后代从怀孕到幼儿期进行了随访。自1983年以来，澳大利亚气质项目第三代研究跟踪了2，443名澳大利亚年轻人从婴儿到成年的15次浪潮，以及自2012年以来从怀孕到幼儿期的1170名后代。达尼丁多学科健康与发展研究“育儿研究”自1972年以来对1,037名新西兰年轻人进行了15次跟踪调查，自1994年以来对730名幼儿进行了跟踪调查。将对常见的孕前暴露和下一代后代结局进行跨队列复制分析，而对汇总数据的综合数据分析将用于罕见暴露和结局。ANZ-ICC代表了一种独特的合作，它将生命周期流行病学，生物统计学，发展心理学和精神病学学科联系起来，研究父母孕前暴露对下一代健康和发展的作用。
The Australian New Zealand Intergenerational Cohort Consortium (ANZ-ICC) brings together three of the longest running intergenerational cohort studies in Australia and New Zealand to examine the extent to which preconception parental life histories (from infancy to parenthood) predict next generation early health and development. The aims are threefold: (1) to describe pathways of advantage that strengthen emotional health and well-being from one generation to the next, (2) to describe pathways of disadvantage that perpetuate cycles of emotional and behavioural problems across generations, and (3) to identify modifiable factors capable of breaking intergenerational cycles. The Victorian Intergenerational Health Cohort Study has followed 1,943 young Australians from adolescence to adulthood across ten waves since 1992, and 1,030 offspring from pregnancy to early childhood since 2006. The Australian Temperament Project Generation 3 Study has followed 2,443 young Australians from infancy to adulthood across 15 waves since 1983, and 1170 offspring from pregnancy to early childhood since 2012. The Dunedin Multidisciplinary Health and Development Study Parenting Study has followed 1,037 young New Zealanders across 15 waves since 1972, and 730 offspring in early childhood since 1994. Cross-cohort replication analyses will be conducted for common preconception exposures and next generation offspring outcomes, while integrated data analysis of pooled data will be used for rare exposures and outcomes. The ANZ-ICC represents a unique collaboration that bridges the disciplines of lifecourse epidemiology, biostatistics, developmental psychology and psychiatry, to study the role of parental preconception exposures on next generation health and development.