Somatic symptoms and HIV infection: relationship to depressive symptoms and indicators of HIV disease.
Somatic symptoms and HIV infection: relationship to depressive symptoms and indicators of HIV disease.
复制标题
躯体症状和艾滋病毒感染：与抑郁症状和艾滋病毒疾病指标的关系。
DOI：
10.1176/ajp.152.12.1776
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Evans,DL
中科院分区：
文献类型：
--
作者：
Perkins,DO;Leserman,J;Stern,RA;Baum,SF;Liao,D;Golden,RN;Evans,DL
本研究探讨的躯体症状疲劳和失眠与精神障碍和HIV疾病severity.MethodStudy参与者的指标的关系是98无症状的HIV感染者和71未感染的同性恋男性; 82 HIV感染者和64未感染的男性有6个月的随访检查。来自自我报告的情绪状态量表测量疲劳和烦躁情绪。重性抑郁症的诊断由DSM-III-R的结构化临床访谈确定。从汉密尔顿抑郁和焦虑量表中选择的项目测量失眠和其他抑郁症状。电池的标准化测试的性能确定neuropsychological function ratings.ResultsAt study entry，疲劳和失眠的投诉与烦躁不安的情绪，抑郁症，和其他非HIV相关的症状，抑郁症，但不与CD 4细胞计数或神经心理功能。在6个月的随访期间，疲劳和失眠水平的增加与非HIV相关的抑郁症状和焦虑情绪的严重程度增加有关。疲劳的增加也与运动功能的下降有关。否则，疲劳或失眠与HIV疾病progress.ConclusionsThese研究结果表明，在其他无症状的HIV感染者的疲劳和失眠的投诉可能与心理障碍，并可能严重抑郁症，这是可以治疗的。抱怨疲劳或失眠的艾滋病毒感染者应定期进行重度抑郁症评估。
ObjectiveThis study examined the relationship of the somatic symptoms fatigue and insomnia with indicators of both psychiatric disturbance and HIV disease severity.MethodStudy participants were 98 asymptomatic HIV-infected and 71 uninfected homosexual men; 82 HIV-infected and 64 uninfected men had 6-month follow-up examinations. Scales from the self-reported Profile of Mood States measured fatigue and dysphoric mood. Major depression diagnosis was determined by the Structured Clinical Interview for DSM-III-R. Selected items from the Hamilton depression and anxiety scales measured insomnia and other symptoms of depression. Performance on a battery of standardized tests determined neuropsychological function ratings.ResultsAt study entry, complaints of fatigue and insomnia were associated with dysphoric mood, major depression, and other non-HIV-related symptoms of major depression but not with CD4 cell counts or neuropsychological functioning. Increases in levels of fatigue and insomnia over the 6-month follow-up period were associated with increases in non-HIV-related symptoms of depression and in severity of dysphoric mood. Increases in fatigue were also associated with decrements in motor functioning. Otherwise, fatigue or insomnia were not associated with HIV disease progression.ConclusionsThese findings suggest that complaints of fatigue and insomnia in otherwise asymptomatic HIV-infected patients are likely to be related to psychological disturbances and possibly major depression, which can be treated. HIV-infected patients who complain of fatigue or insomnia should routinely be assessed for major depression.