Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function.
Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function.
复制标题
雌激素对雌性大鼠腹侧中脑酪氨酸羟化酶免疫反应细胞的影响：多巴胺功能双细胞假说的进一步证据。
DOI：
10.1016/s0006-8993(00)02323-4
复制
发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
Naftolin,F
中科院分区：
文献类型：
--
作者：
Zsarnovszky,A;Scalise,TJ;Horvath,TL;Naftolin,F
The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell counting of TH-immunoreactive perikarya of the SNc, paranigral (PN) and interfascicular (IF) nucleus was performed and compared. Our findings demonstrate that E eliminated TH immunoreactivity from a number of midbrain neurons, while it seemingly did not affect it in others. This signifies a differential effect of E on ventral mesencephalic dopaminergic neurons.
