A morphometric reevaluation of Huntington's chorea with special reference to the large neurons in the neostriatum.
A morphometric reevaluation of Huntington's chorea with special reference to the large neurons in the neostriatum.
复制标题
对亨廷顿舞蹈症的形态测量重新评估，特别涉及新纹状体中的大神经元。
作者：
K. Oyanagi;F. Ikuta
为了重新评价亨廷顿舞蹈病（HC）新纹状体的数量变化，对4例HC和5例对照组的尾状核和壳核切片进行Klüver-Barrera染色，用数字化仪测量神经元的核面积。不同大小的神经元的数量进行了统计学评估。该研究揭示了HC的新纹状体中大神经元（核面积;大于121微米2）的数量的显著减少以及小神经元（核面积;小于80微米2）的数量的严重减少。在尾状核头和壳核的上部和下部有平行程度的神经元丢失。神经元丢失的程度在壳核中比在尾状头中稍微更严重。大神经元的耗竭与小神经元的损失无关。中等大小的神经元（核面积; 81-120微米2）的数量没有显示出统计学上的显著变化。
In order to reevaluate the quantitative changes in the neostriatum of Huntington's chorea (HC), sections of the caudate head and putamen from 4 HC and 5 control cases were treated with Klüver-Barrera stain and the nuclear area of the neurons was measured by a digitizer. The number of neurons of different sizes was evaluated statistically. This study revealed a significant decrease in the number of large neurons (nuclear area; greater than 121 microns 2) as well as a severe decrease in the number of small neurons (nuclear area; less than 80 microns 2) in the neostriatum of HC. There was a parallel degree of neuronal loss in the upper and lower portions of both caudate head and putamen. The degree of neuronal loss was slightly more severe in the putamen than in the caudate head. The depletion of the large neurons was not correlated with the loss of small neurons. The number of medium-sized neurons (nuclear area; 81-120 microns 2) showed no statistically significant change.