A GOLGI-STUDY OF THE NEURONAL POPULATION OF THE MARGINAL ZONE (LAMINA-I) OF THE RAT SPINAL-CORD
A GOLGI-STUDY OF THE NEURONAL POPULATION OF THE MARGINAL ZONE (LAMINA-I) OF THE RAT SPINAL-CORD
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DOI：
10.1002/cne.902440105
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发表时间：
1986-02-01
影响因子：
2.5
通讯作者：
COIMBRA, A
中科院分区：
文献类型：
--
作者：
LIMA, D;COIMBRA, A
以树突构筑和胞体形态为基础，辅以树突分支的形态计量学方法，在大鼠脊髓I板层内可区分出四种主要神经元类型。(I)梭形刺细胞(39%的受孕神经元)具有纵向纺锤形的果皮，具有双极，较少见单极，树状树富含有蒂的刺和细小的串珠的纵向轴突；这类神经元主要出现在侧缘区域。在Ia型细胞(占总数的33%)中，树突域占据一个狭窄的纵向区域，而在Ib型细胞(6%)中，极树突起部分分布在腹侧。梭形神经元被认为是与外侧板层的纵向传入神经丛相连的固有细胞，在Ib型细胞中也接受胶状质的初级输入。(Ii)多极细胞(23%)具有密集的树枝状乔木，由许多初级树干组成，主要分布在内侧边缘地带。树突在IIA型细胞中呈中等程度的背腹伸展，在较大的IIB型细胞中可达III层。前者有多种棘突、轴突，有时还有无髓轴突，推测为中间神经元，而IIB型细胞表现为粗大的锥形轴突，可能是有髓轴突。(Iii)扁平的棘状神经元(13%)，其多边形体在水平面上呈扁平状，水平树状突起局限于I层，这些细胞主要分布在I层中段；(Iv)锥体神经元(25%)具有纵向延长的突入白质的核周。乔木具有较大的纵向和向外扩展，并包括在白质中分叉的分支。III型和IV型显示了古老文献中经典的边缘细胞向内侧延长的方向；它们显示了粗大的锥形轴突，可能构成了大鼠I层投射神经元的大部分。
On the basis of dendroarchitecture and cell body shape, complemented with morphometry of dendritic ramification, four major neuronal types were distinguished in lamina I of the spinal cord of the rat. (I) Fusiform spiny cells (39% of impregnated neurons) have longitudinal spindle-shaped perikarya with bipolar, less frequently unipolar, dendritic trees rich in pedicled spines and a thin, beaded longitudinal axon; such neurons occur mainly in the lateral marginal zone. In type IA cells (33% of the total), the dendritic domain occupies a narrow longitudinal area, while in type Ib cells (6%) the polar dendritic trees partly arborize ventrally. Fusiform neurons are considered intrinsic cells connected with the longitudinal afferent plexus in lateral lamina I, and in type IB cells also receiving primary input in the substantia gelatinosa. (II) Multipolar cells (23%) have a dense dendritic arbor orginating from numerous primary trunks and they predominate in the medial marginal zone. The dendritic arbor is moderately extended dorsoventrally in type IIA cells and reaches lamina III in the larger type IIB cells. The former possess a variety of spines, axonlike processes and sometimes an unmyelinated axon, and are presumably interneurons, while type IIB cells show a thick tapering axon that is probably myelinated. (III) Flattened aspiny neurons (13%) with a polygonal body flattened in the horizontal plane, and a horizontal dendritic arbor confined to lamina I; these cells predominate in middle lamina I. (IV) Pyramidal neurons (25%) have longitudinally elongated perikarya that bulge into the white matter. The arbor has a large longitudinal and lateromedial spread and includes branches which ramify in the white matter. Types III and IV show the classical lateromedially elongated orientation of the marginal cells of the old literature; they show thick tapering axons and probably make up the bulk of the projection neurons of rat lamina I.