EFFECT OF ZINC SUPPLEMENTATION ON THE DIETARY-INTAKE, RATE OF WEIGHT-GAIN, AND ENERGY-COST OF TISSUE DEPOSITION IN CHILDREN RECOVERING FROM SEVERE MALNUTRITION
EFFECT OF ZINC SUPPLEMENTATION ON THE DIETARY-INTAKE, RATE OF WEIGHT-GAIN, AND ENERGY-COST OF TISSUE DEPOSITION IN CHILDREN RECOVERING FROM SEVERE MALNUTRITION
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DOI：
10.1093/ajcn/34.5.900
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发表时间：
1981-01-01
影响因子：
7.1
通讯作者：
GOLDEN, BE
中科院分区：
文献类型：
--
作者：
GOLDEN, MHN;GOLDEN, BE
从严重营养不良中恢复的以牛奶为基础的饮食的儿童血浆锌浓度较低：恢复以大豆为基础的饮食的儿童血浆锌浓度较低，体重增加率较低，组织沉积的能量成本较高。他们没有表现出厌食症，腹泻和皮肤病变通常与锌缺乏症的临床特征。儿童（16）补充醋酸锌的基础上，锌的治疗反应构成了预先存在的锌缺乏症的最佳证据。在这16名儿童中，有14名儿童在补充锌后体重增加率立即明确增加。这与组织沉积、胸腺再生和Na泵激活的能量消耗减少有关。孩子们缺锌。缺锌的厌食症可能与缺锌状态下无法代谢N有关;由于所用饮食的蛋白质含量相对较低，儿童没有表现出食欲反应。在这些儿童中观察到的异常可能继发于轻度缺锌;瘦组织合成的限制，导致肥胖，以及感染倾向显然是轻度缺锌的主要特征。经历一段时间的追赶体重增加或增长的儿童应该补充锌，特别是如果他们有腹泻或如果使用大豆为基础的配方是考虑。
Children recovering from severe malnutrition on a milk-based diet have low plasma Zn concentrations: children recovering on a soya-based diet have lower plasma Zn concentrations, lower rates of weight gain and higher energy costs of tissue deposition. They do not demonstrate the clinical features of anorexia, diarrhea and skin lesions usually associated with Zn deficiency. Children (16) were supplemented with zinc acetate on the basis that a therapeutic response to Zn constitutes the best evidence of a preexisting Zn deficiency. Of the 16 children, 14 had an immediate and definite increase in their rate of weight gain with Zn supplementation. This was associated with a decrease in the energy cost of tissue deposition, regrowth of the thymus, and activation of the Na pump. The children were Zn deficient. The anorexia of Zn deficiency may be related to an inability to metabolize N in the Zn deficient state; the children did not show an appetitive response because of the relatively low protein content of the diets used. The abnormalities seen in these children may be secondary to mild Zn deficiency; limitation of lean tissue synthesis, with resultant obesity, and a propensity to infection evidently are the major features of a mild Zn deficiency. Children undergoing a period of catch-up weight gain or growth should have supplemental Zn, particularly if they had diarrhea or if the use of a soya-based formula is contemplated.