THE NATURE OF THE OTOTOXIC ACTIONS OF ETHACRYNIC-ACID UPON THE MAMMALIAN ENDOLYMPH SYSTEM .1. FUNCTIONAL-ASPECTS
THE NATURE OF THE OTOTOXIC ACTIONS OF ETHACRYNIC-ACID UPON THE MAMMALIAN ENDOLYMPH SYSTEM .1. FUNCTIONAL-ASPECTS
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DOI：
10.3109/00016488009127156
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发表时间：
1980-01-01
影响因子：
1.4
通讯作者：
BOSHER, SK
中科院分区：
文献类型：
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作者：
BOSHER, SK
静脉注射产生的内淋巴变化。用常规微电极和离子敏感微电极(Na+、K+和pH)对大鼠注射60 mg/kg的乙丙烯酸进行长达120min的追踪。它们是由3种不同的对内淋巴系统的影响引起的。最初，该药物完全抑制了工业电位的产生和阳离子的运输过程。复苏开始得很快，一开始也很快。随后，其发生率明显下降，可能是由于起病延迟和持续时间延长的工业能量生产减少所致。与主动转运的这些作用相一致的是，内淋巴系统的整体阳离子通透性降低。这遵循了不同的时间进程，对K+的影响比对Na+的影响大得多。这些发现还提供了有关正常内淋巴成分的机制的进一步信息。在对豚鼠进行的一项附属研究中也得到了定性上类似的结果。
The endolymphatic changes produced by an i.v. injection of 60 mg/kg ethacrynic acid were followed for up to 120 min using conventional and ion-sensitive (Na+, K+ and pH) microelectrodes in the rat. They were caused by 3 distinct effects upon the endolymph system. Initially, the drug completely inhibited the strial potential-producing and cation-transporting processes. Recovery began quickly and was rapid at first. Then its rate declined considerably, probably due to diminution in strial energy production of delayed onset and prolonged duration. Coincident with these actions upon active transport, there was a decrease in the overall cation permeability of the endolymph system. This followed a different time course and affected K+ much more than Na+. The findings also provided further information about the mechanisms responsible for the normal endolymphatic composition. Qualitatively similar results were obtained in a subsidiary study on guinea pigs.