BCL-2 PROTOONCOGENE PROTEIN IMMUNOREACTIVITY IN NORMALLY DEVELOPING AND AXOTOMISED RAT RETINAS
BCL-2 PROTOONCOGENE PROTEIN IMMUNOREACTIVITY IN NORMALLY DEVELOPING AND AXOTOMISED RAT RETINAS
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DOI：
10.1016/0304-3940(94)90650-5
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发表时间：
1994-05-19
影响因子：
2.5
通讯作者：
JEN, LS
中科院分区：
文献类型：
--
作者：
CHEN, ST;GAREY, LJ;JEN, LS
这项研究表明，bcl-2（B细胞淋巴瘤）的原癌基因蛋白表达的两个群体的视网膜细胞，一个在视网膜内层代表发育中的神经元或神经胶质细胞在围产期阶段，和其他确定为穆勒细胞从出生后第10天起。在新生大鼠视束损伤或视神经切断后，Müller细胞突起中bcl-2免疫反应性增加。这些结果提示，bcl-2蛋白可能在视网膜内层细胞的分化、成熟和稳态中起作用，其在Muller细胞中的表达可被神经节细胞的变性所上调。
This study demonstrates immunocytochemically that bcl-2 (B cell lymphoma) proto-oncogene protein is expressed by two populations of retinal cells, one in the inner retina representing developing neurons or glia at perinatal stages, and the other identified as Muller cells from postnatal day 10 onward. An increase in bcl-2 immunoreactivity was detected in the Muller cell processes after neonatal optic tract lesion or optic nerve transection in adult rats. These results suggest that bcl-2 protein may function on cellular differentiation, maturation and homeostasis in the inner retina, and its expression by Muller cells can be up-regulated by the degeneration of ganglion cells.