Precision of extracting absorption profiles from weakly scattering media with spectroscopic time-domain optical coherence tomography
Precision of extracting absorption profiles from weakly scattering media with spectroscopic time-domain optical coherence tomography
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DOI：
10.1364/opex.12.001677
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发表时间：
2004-04-19
期刊：
影响因子：
3.8
通讯作者：
Drexler, W
中科院分区：
文献类型：
--
作者：
Hermann, B;Bizheva, K;Drexler, W
利用最先进的超宽带Ti: Al2O3激光器（lambda(c) = 800 nm, Deltalambda = 260 nm, P-out = 120 mW），研究了光谱光学相干层析成像（SOCT）在弱散射介质中嵌入的发色团的空间局域吸收谱的可行性。该方法的精度与色团吸收、样品厚度以及与测量过程相关的不同参数有关，并在单层和多层模型中进行了理论和实验评估。结果表明，在弱散射介质中，SOCT能够从450 mm厚的幽灵中提取出小至0.5 mm（-1）的mu(a)(lambda)，其中心精度接近2%，所用波长区域边缘精度接近8%。正如预期的那样，在吸收特性相同且厚度接近180 μ m的幻影中，在中心波长区域，SOCT的精度下降到bb1010%。(C) 2004美国光学学会。
The feasibility of spectroscopic optical coherence tomography (SOCT) to quantify spatially localized absorption profiles of chromophores embedded in weakly scattering media with a single measurement over the full spectral bandwidth of the light source was investigated by using a state-of-the-art ultra-broad bandwidth Ti: Al2O3 laser (lambda(c) = 800 nm, Deltalambda = 260 nm, P-out = 120 mW ex- fiber). The precision of the method as a function of the chromophore absorption, the sample thickness, and different parameters related to the measurement procedure was evaluated both theoretically and experimentally in single and multilayered phantoms. It is demonstrated that in weakly scattering media SOCT is able to extract mu(a)(lambda) as small as 0.5 mm(-1) from 450 mum thick phantoms with a precision of similar to2% in the central and similar to8% at the edges of the used wavelength region. As expected, in phantoms with the same absorption properties and thickness similar to180 mum the precision of SOCT decreases to >10% in the central wavelength region. (C) 2004 Optical Society of America.