Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study
Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study
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DOI：
10.1016/j.jpeds.2006.04.065
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发表时间：
2006-09-01
影响因子：
5.1
通讯作者：
Rodriguez, Beatriz L.
中科院分区：
文献类型：
--
作者：
Kershnar, Ann K.;Daniels, Stephen R.;Rodriguez, Beatriz L.
目的评估美国青年1型或2型糖尿病患者血脂异常的患病率。研究设计青年糖尿病研究是一项横断面、基于人群的研究，在六个中心进行。研究对象为2448名接受研究检查的青年糖尿病患者。结果测量是空腹总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯和非HDL-C的测量。分析是描述性的。结果总TC浓度高（> 240 mg/dL）的患病率为5%；高LDL-C （> 160 mg/dL）的总体患病率为3%，高甘油三酯（> 400 mg/dL）的总体患病率为2%。大约一半的参与者（48%）的LDL-C浓度高于100毫克/分升的最佳水平。在10岁以上的青少年中，2型糖尿病（n = 283）的血脂异常患病率高于1型糖尿病（n = 1963）： 33%对19%的TC浓度为200 mg/dL；24%对15%的患者LDL-C浓度为130 mg/dL；29% vs 10%的患者甘油三酯浓度为150 mg/dL；44%和12%的患者HDL-C浓度< 40 mg/dL。只有1%的年轻人接受了针对血脂异常的药物治疗。结论年轻糖尿病患者血脂异常占相当大比例。
Objective Assessment of the prevalence of serum lipid abnormalities in US youth with type 1 or type 2 diabetes.Study design The SEARCH for Diabetes in Youth Study was a cross-sectional, population-based study, conducted in six centers. Subjects were 2448 youth with diabetes who had a study examination. Outcome measures were fasting measures of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and non-HDL-C. Analysis was descriptive.Results The overall prevalence of high TC concentration (> 240 mg/dL) was 5%; the overall prevalence of high LDL-C (> 160 mg/dL) was 3%, and the overall prevalence of high triglyceride (> 400 mg/dL) was 2%. About half of the participants (48%) had an LDL-C concentration above the optimal level of 100 mg/dL. Among youth ages 10+, the prevalence of abnormal lipids was higher in type 2 (n = 283) than in type 1 diabetes (n = 1963): 33% versus 19% had TC concentration > 200 mg/dL; 24% versus 15% had LDL-C concentration > 130 mg/dL; 29% versus 10% had triglyceride concentration > 150 mg/dL; 44% versus 12% had HDL-C concentration < 40 mg/dL. Only 1% of youth were receiving pharmacologic therapy for dyslipidemia.Conclusions A substantial proportion of young patients with diabetes have abnormal serum lipids.