Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost.
Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost.
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仅在发生大量体重减轻并与减肥幅度相关后，才能观察到胃旁路手术后的外周葡萄糖吸收的改善。
DOI：
10.1007/s11605-009-1060-y
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发表时间：
2010-01
影响因子：
3.2
通讯作者：
Mulligan, Kathleen
中科院分区：
文献类型：
--
作者：
Campos, Guilherme M.;Rabl, Charlotte;Peeva, Sofia;Ciovica, Ruxandra;Rao, Madhu;Schwarz, Jean-Marc;Havel, Peter;Schambelan, Morris;Mulligan, Kathleen
关键词：
在Roux-en-Y胃旁路手术(RYGB)后，肠道和胰腺激素分泌的改变可能有助于胰岛素抵抗的缓解，但体重减轻和激素分泌对外周葡萄糖处置的独立影响尚不清楚。对两组非糖尿病病态肥胖患者进行了研究：RYGB+标准化热量限制(RYGB，n = 12)或单纯热量限制(Dial，n = 10)。在RYGB治疗前、治疗后14天(两组)和6个月(6个月)进行代谢评估(正常血糖-高胰岛素钳夹试验、餐耐量试验)。在基线时，身体成分、空腹胰岛素、血糖和外周葡萄糖处置在组间没有差异。在第14天，过量体重减轻与饮食相似(RYGB，12.7%对饮食，10.9%；p = 0.12)，空腹胰岛素和血糖下降幅度相似，RYGB受试者改变了餐后肠道和胰腺激素分泌的模式。然而，两组患者的外周葡萄糖摄取量(M值)均无变化。RYGB治疗6个月后EWL为49.7%。空腹血糖和胰岛素水平以及胃肠激素分泌的变化持续存在。M值明显改善，并与%EWL呈正相关(r = 0.6 8，p = 0.0 2)。RYGB治疗后外周葡萄糖摄取的改善只有在体重显著下降后才能观察到，并与体重下降的幅度相关。
Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown. Two groups of nondiabetic morbidly obese patients were studied: RYGB followed by standardized caloric restriction (RYGB, n = 12) or caloric restriction alone (diet, n = 10). Metabolic evaluations (euglycemic–hyperinsulinemic clamp, meal tolerance test) were done at baseline and 14 days (both groups) and 6 months after RYGB. At baseline, body composition, fasting insulin, and glucose and peripheral glucose disposal did not differ between groups. At 14 days, excess weight loss (EWL) was similar (RYGB, 12.7% vs. diet, 10.9%; p = 0.12), fasting insulin and glucose decreased to a similar extent, and RYGB subjects had altered postmeal patterns of gut and pancreatic hormone secretion. However, peripheral glucose uptake (M value) was unchanged in both groups. Six months after RYGB, EWL was 49.7%. The changes in fasting glucose and insulin levels and gut hormone secretion persisted. M values improved significantly, and changes in M values correlated with the % EWL (r = 0.68, p = 0.02). Improvement in peripheral glucose uptake following RYGB was observed only after substantial weight loss had occurred and correlated with the magnitude of weight lost.
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影响因子：
--
作者：
Hagemann, Dirk;Holst, Jens J.;Meier, Juris J.
通讯作者：
Meier, Juris J.
影响因子：
5.8
作者：
Laferrere, Blandine;Teixeira, Julio;Olivan, Blanca
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影响因子：
16.2
作者：
Laferrere, Blandine;Heshka, Stanley;Olivan, Blanca
通讯作者：
Olivan, Blanca
影响因子：
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作者：
Cummings, D. E.
通讯作者：
Cummings, D. E.
影响因子：
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作者：
Ellsmere, James C.;Thompson, Christopher C.;Kaplan, Lee M.
通讯作者：
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