Pharmacological prophylaxis in the kindling model of epilepsy.
Pharmacological prophylaxis in the kindling model of epilepsy.
复制标题
癫痫点燃模型的药物预防。
作者：
J. Wada
迄今为止，通过癫痫点燃模型对抗癫痫药物评估的回顾表明，它填补了标准筛选方法（如最大电休克或戊四氮筛选试验）中明显的空白。然而，为了获得抗癫痫药物关于通过点燃制剂预防发展中癫痫发作和治疗已确定癫痫发作的全面概况，需要具有以下内容：（1）点燃技术的标准化，（2）检查药物对发展中癫痫发作的作用，（3）使用各种动物物种，涉及不同的功能性脑部位，和（4）监测所施用药物的血浆水平。据设想，明智地使用点燃制剂也可能使我们对药物产生预防或治疗作用的机制有一些了解。
Review of antiepileptic drug assessment to date by means of the kindling model of epilepsy suggests that it fills a gap that is evident in standard screening methods such as maximum electroshock or pentylenetetrazol screening tests. However, in order to obtain a comprehensive profile of antiepileptic drugs regarding prophylaxis of developing seizures and treatment of well-established seizures through the kindling preparation, it is desirable to have the following: (1) standardization of kindling techniques, (2) examination of drug effects on developing as opposed to developed seizures, (3) use of a variety of animal species, involving different functional brain sites, and (4) monitoring of plasma levels of the drug administered. It is envisaged that judicious use of the kindling preparation might also enable us to gain some insight into the mechanisms by which drugs produce their prophylactic or therapeutic effect.