Atheroarteritis: a combined immunological and lipid imbalance.
Atheroarteritis: a combined immunological and lipid imbalance.
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动脉粥样硬化：免疫和脂质失衡的综合表现。
DOI：
10.1016/s0167-5273(96)88772-9
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发表时间：
1996
影响因子：
3.5
通讯作者：
Group,PD
中科院分区：
文献类型：
--
作者：
Wissler,RW;Group,PD
本报告追溯了从 20 世纪初至今我们对免疫复合物动脉炎的了解的发展。重点是从 Longcope、MacKenzie 和 Rich 对血清病的开创性观察开始的工作，到多个小组对兔子血清病动脉炎的发病机制研究，包括 Dixon 及其同事在循环免疫复合物的作用方面的杰出贡献。在这项工作之后，Minick 等人的持续研究揭示了与动脉粥样硬化的关系。对高胆固醇血症兔血清病性动脉炎的影响。这项开创性的研究工作最近对于了解某些灵长类动物（如食蟹猴和线虫）、人类红斑狼疮和器官移植动脉炎中观察到的动脉炎具有关键价值。最近，这种类型的免疫复合物损伤的微观特征之一变得明显，那就是炎性动脉病变的同心微结构，当它们也含有脂质时，我们创造了术语动脉粥样硬化。糖基化低密度脂蛋白和氧化低密度脂蛋白的新抗原对这种类型动脉粥样硬化的发生的贡献被考虑。 PDAY 研究开辟了这一研究领域的新前沿，该研究提供了将循环免疫复合物和新抗原与动脉炎及其加速的狭窄动脉病变发展联系起来的新机会。
This report traces the development of our knowledge about immune-complex arteritis from the early 20th Century to the present time. The emphasis is on the work which began with the seminal observations of serum sickness by Longcope, MacKenzie, and Rich, to the pathogenetic studies of serum sickness arteritis in rabbits by serveral groups including the outstanding contributions by Dixon and coworkers concerning the role of circulating immune complexes. This work was followed by investigations of the relationship to atherosclerosis revealed by the sustained studiesl by Minick et al. on serum sickness arteritis in hypercholesterolemic rabbits. This pioneering research work has more recently been of pivotal value in understanding the arteritis observed in certain primate species such as the cynomolgus and the nemestrina, in human lupus erythematosus, and in organ transplantion arteritis. More recently it has become apparent that one of the microscopic hallmarks of this type of immune complex injury is the concentic microarchitecture of the inflammatory arterial lesions, for which, when they are also lipid containing, we have coined the term artheroarteritis. The contributions of the neoantigens from glycosylated LDL and oxidized LDL to the development of this type of atheroarteritis are considered. New frontiers in this area of research are being opened by the PDAY study which offers new opportunities to link circulating immune complexes and new antigens to arheroarteritis with its accelerated stenotic arterial lesion development.