Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency.
Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency.
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DOI：
10.1007/s10875-022-01296-4
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发表时间：
2022-08
影响因子：
9.1
通讯作者：
Kang, Insoo
中科院分区：
文献类型：
--
作者：
Shin, Junghee Jenny;Par-Young, Jennefer;Unlu, Serhan;McNamara, Andrew;Park, Hong-Jai;Shin, Min Sun;Gee, Renelle J.;Doyle, Hester;Afinogenova, Yuliya;Zidan, Elena;Kwah, Jason;Russo, Armand;Mamula, Mark;Hsu, Florence Ida;Catanzaro, Jason;Racke, Michael;Bucala, Richard;Wilen, Craig;Kang, Insoo
关键词：
一抗缺陷 (PAD) 患者对 2019 冠状病毒病 (COVID-19) mRNA 疫苗的免疫反应在很大程度上尚不清楚。我们研究了疫苗接种前后针对 SARS-CoV-2 刺突蛋白 (S) 的抗体和 CD4+ T 细胞特异性反应，以及疫苗反应与 PAD 患者临床和免疫学特征之间的关联。 PAD 队列由常见变异免疫缺陷 (CVID) 和其他 PAD 组成，不符合 CVID 诊断 (oPAD) 标准。接种疫苗后，抗 S IgG、IgA 以及 IgG 亚类 1 和 3 增加，并与 HC 和 oPAD 患者的中和活性相关。然而，42% 的 CVID 患者在第二次给药后出现了这种反应。通过 OX40 和 4-1BB 表达确定，S 特异性 CD4+ T 细胞也观察到类似的模式。与具有足够抗 S IgG 反应的患者相比，抗 S IgG 反应较差的患者的基线 IgG、IgA、CD19+ B 细胞、转换记忆 B 细胞、初始 CD8+ T 细胞水平显着较低，并且 EM CD8+ T 细胞和自身免疫的频率较高。 oPAD 患者可以对疫苗产生类似于 HC 的体液和细胞免疫反应。然而，一部分 CVID 患者在产生此类反应方面表现出障碍，这可以通过基线免疫特征和自身免疫病史来预测。在线版本包含可在 10.1007/s10875-022-01296-4 获取的补充材料。
Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4+ T-cell responses specific for SARS-CoV-2 spike protein (S) before and after vaccination and associations between vaccine response and patients’ clinical and immunological characteristics in PADs. The PAD cohort consisted of common variable immune deficiency (CVID) and other PADs, not meeting the criteria for CVID diagnosis (oPADs). Anti-S IgG, IgA, and IgG subclasses 1 and 3 increased after vaccination and correlated with neutralization activity in HCs and patients with oPADs. However, 42% of CVID patients developed such responses after the 2nd dose. A similar pattern was also observed with S-specific CD4+ T-cells as determined by OX40 and 4-1BB expression. Patients with poor anti-S IgG response had significantly lower levels of baseline IgG, IgA, CD19+ B-cells, switched memory B-cells, naïve CD8+ T-cells, and a higher frequency of EM CD8+ T-cells and autoimmunity compared to patients with adequate anti-S IgG responses. Patients with oPADs can develop humoral and cellular immune responses to vaccines similar to HCs. However, a subset of CVID patients exhibit impairment in developing such responses, which can be predicted by the baseline immune profile and history of autoimmunity. The online version contains supplementary material available at 10.1007/s10875-022-01296-4.
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影响因子：
9.1
作者：
Shin JJ;Catanzaro J;Yonkof JR;Delmonte O;Sacco K;Shin MS;Reddy S;Whittington PJ;Soffer G;Mustillo PJ;Sullivan KE;Notarangelo LD;Abraham RS;Romberg N;Kang I
通讯作者：
Kang I
影响因子：
7.3
作者：
Amodio D;Ruggiero A;Sgrulletti M;Pighi C;Cotugno N;Medri C;Morrocchi E;Colagrossi L;Russo C;Zaffina S;Di Matteo G;Cifaldi C;Di Cesare S;Rivalta B;Pacillo L;Santilli V;Giancotta C;Manno EC;Ciofi Degli Atti M;Raponi M;Rossi P;Finocchi A;Cancrini C;Perno CF;Moschese V;Palma P
通讯作者：
Palma P
影响因子：
3.7
作者：
Reiss, Samantha;Baxter, Amy E.;Kaufmann, Daniel E.
通讯作者：
Kaufmann, Daniel E.
影响因子：
9.1
作者：
Picard C;Bobby Gaspar H;Al-Herz W;Bousfiha A;Casanova JL;Chatila T;Crow YJ;Cunningham-Rundles C;Etzioni A;Franco JL;Holland SM;Klein C;Morio T;Ochs HD;Oksenhendler E;Puck J;Tang MLK;Tangye SG;Torgerson TR;Sullivan KE
通讯作者：
Sullivan KE
影响因子：
5.5
作者：
Kim, Jung-Sik;Cho, Bon-A;Kim, Hang-Rae
通讯作者：
Kim, Hang-Rae