CDK INHIBITORS - ON THE THRESHOLD OF CHECKPOINTS AND DEVELOPMENT
CDK INHIBITORS - ON THE THRESHOLD OF CHECKPOINTS AND DEVELOPMENT
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DOI：
10.1016/0955-0674(94)90055-8
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发表时间：
1994-12-01
影响因子：
7.5
通讯作者：
HARPER, JW
中科院分区：
文献类型：
--
作者：
ELLEDGE, SJ;HARPER, JW
周期蛋白依赖性激酶的调节是细胞周期控制的核心，由此推断，细胞增殖的控制。最近在调节这些激酶方面的进展发现了一组与它们结合并抑制它们的小蛋白质，从而阻止细胞周期的进展。将这些蛋白质与肿瘤抑制功能联系起来，为癌症和细胞周期控制之间的联系提供了一个备受寻求的途径。
The regulation of cyclin-dependent kinases is at the heart of cell cycle control and, by inference, the control of cell proliferation. Recent advances in regulation or these kinases have uncovered a group of small proteins that bind to and inhibit them, thus preventing cell cycle progression. Linking these proteins to tumor suppressor functions has provided a much sought after connection between cancer and cell cycle control.