Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces
Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces
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DOI：
10.1002/jbm.a.32387
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Gibson, Lorna J.
中科院分区：
文献类型：
--
作者：
Harley, Brendan A.;Lynn, Andrew K.;Gibson, Lorna J.
需要改进目前关节软骨损伤的治疗方法。这篇文章是描述基于胶原-糖胺聚糖和磷酸钙技术的骨软骨支架的设计和开发的系列文章中的第三篇，用于关节软骨缺损的再生修复。本系列的前几篇文章描述了制备多孔三维矿化胶原-GAG（CGCaP）支架的方法，其组成可以重复变化以模拟软骨下骨的组成，并且可以改变孔微结构和矿物质相。这篇文章描述了一种方法，“液相共合成”，使多孔的，分层的支架，模仿关节软骨的组成和结构的一侧，另一侧的软骨下骨，和连续的，渐进的或“软”这些组织之间的接口：关节关节的潮标的生产。这种设计使得分层支架能够在骨软骨缺损部位插入软骨下骨中，而不需要缝合线、胶水或螺钉，在整个骨软骨缺损中具有高度互连的多孔网络。此外，骨和软骨隔室的不同模量使得这些分层支架能够表现出压缩变形行为，其模拟在天然关节中观察到的行为。(C)2009 Wiley Periodicals，Inc. J Biomed Mater Res 92A：10781093，2010
There is a need to improve Current treatments for articular cartilage injuries. This article is the third in a series describing the design and development of an osteochondral scaffold based on collagen-glycosaminoglycan and calcium phosphate technologies for regenerative repair of articular cartilage defects. The previous articles in this series described methods for producing porous, three-dimensional mineralized collagen-GAG (CGCaP) scaffolds whose composition can be reproducibly varied to mimic the composition of subchondral bone, and pore micro-structure and mineral phase can be modified. This article describes a method, "liquid-phase cosynthesis," that enables the production of porous, layered scaffolds that mimic the composition and structure of articular cartilage on one side, subchondral bone on the other side, and the continuous, gradual or "soft" interface between these tissues: the tidemark of articular joints. This design enables the layered scaffolds to be inserted into the subchondral bone at an osteochondral defect site without the need for sutures, glue, or screws, with a highly interconnected porous network throughout the entire osteochondral defect. Moreover, the differential moduli of the osseous and cartilaginous compartments enable these layered scaffolds to exhibit compressive deformation behavior that mimics the behavior observed in natural articular joints. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 10781093, 2010