Scanning Acoustic Microscope for Quantitative Characterization of Biological Tissues
Scanning Acoustic Microscope for Quantitative Characterization of Biological Tissues
复制标题
用于生物组织定量表征的扫描声学显微镜
DOI：
10.1007/978-1-4613-0725-9_27
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发表时间：
1988
影响因子：
4.8
通讯作者：
F. Dunn
中科院分区：
文献类型：
--
作者：
N. Chubachi;J. Kushibiki;T. Sannomiya;N. Akashi;Motonao Tanaka;H. Okawai;F. Dunn
在医学和生物科学领域，声学显微镜正在被开发为一种实用的研究工具[1-3]。本文介绍了一种反射式扫描声学显微镜系统，它可以在微观尺度上定量测量生物组织的粘弹性性质。该系统在幅度和相位模式下工作，具有以下两个功能：用于显示高空间分辨率的幅度和相位图像的声学成像功能，以及用于确定成像区域中任意点的速度和衰减的定量测量功能。工作频率是可变的，因此可以通过声学特性对组织进行光谱分析。利用假彩色成像的附加功能，可以很容易地提取由于病理退变引起的组织声学特性的空间变化。在100至200 MHz的频率范围内对狗的心肌梗死组织进行了实验。
In the field of medical and biological sciences, an acoustic microscope is being developed as a practical research tool [1–3]. This paper describes a system of reflection-type scanning acoustic microscopy which can measure quantitatively visco-elastic properties of biological tissues on a microscopic scale. This system operates in both amplitude and phase modes with the following two functions; an acoustical imaging function for displaying both amplitude and phase images with high spatial resolution, and a quantitative measurement function for determining both velocity and attenuation at arbitrary points in an imaging area. The operating frequency is variable so that it is possible to make spectroscopic analyses of tissues through acoustic properties. The spatial change of acoustic properties in tissues due to pathological degeneration can be extracted easily by an additional function of false color imaging. Experiments have been performed on dog cardiac infarcted tissue in the frequency range 100 to 200 MHz.