Arthritis in a patient with psoriasis after interferon-alpha therapy for chronic hepatitis C.
Arthritis in a patient with psoriasis after interferon-alpha therapy for chronic hepatitis C.
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银屑病患者在干扰素α治疗慢性丙型肝炎后出现关节炎。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
I. Makino
中科院分区：
文献类型：
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作者：
Y. Makino;H. Tanaka;K. Nakamura;M. Fujita;K. Akiyama;I. Makino
一名27岁的银屑病患者接受了白细胞衍生的干扰素-α治疗慢性持续性丙型肝炎。经过3周的注射，血清丙氨酸转氨酶水平最终正常化后，他开始出现多发性关节炎，银屑病皮损恶化。抗核抗体和类风湿因子检测呈阴性，表明干扰素治疗与血清阴性关节炎的发生直接相关。
A 27-year-old man with psoriasis was administered with leukocyte derived interferon-alpha for the treatment of chronic persistent hepatitis C. After 3 weeks of injections and eventual normalization of serum levels of alanine aminotransferase, he began to experience polyarthritis, with worsening of psoriatic skin lesions. Tests for antinuclear antibodies and rheumatoid factor were negative, indicating a direct association between interferon therapy and occurrence of seronegative arthritis.