Ethnic differences in survival among women with ovarian carcinoma
Ethnic differences in survival among women with ovarian carcinoma
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DOI：
10.1002/cncr.10415
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发表时间：
2002-03-15
期刊：
影响因子：
6.2
通讯作者：
Schwartz, AG
中科院分区：
文献类型：
--
作者：
Barnholtz-Sloan, JS;Tainsky, MA;Schwartz, AG
背景资料。在所有女性生殖恶性肿瘤中，卵巢癌是最主要的死亡原因。高加索妇女和非裔美国妇女在年龄调整后的发病率和存活率方面有很大差异。这项研究的目的是在以人群为基础的女性样本中检查卵巢癌后存活率的种族差异。对13,083例(高加索女性12285例，非裔美国女性798例)从人群监测、流行病学和最终结果计划中确诊为卵巢癌的患者进行分析，用优势比估计预后变量与种族之间的关联，用卡方检验确定这些关联的统计学意义(使用双侧P值)。结果：与高加索女性相比，非裔美国女性在确诊时明显更年轻，单身的可能性更大，接受特定部位手术的可能性更小。此外，非洲裔美国女性的粗略中位生存期比高加索女性少近一年(分别为22个月和32个月；P<；0.0001)，在调整了两个种族之间所有其他预后变量后，非裔美国女性死于任何原因的风险增加了30%。结论：与被诊断为卵巢癌的高加索女性相比，被诊断为卵巢癌的非裔美国女性死于任何原因的风险显著增加。(C)2002年美国癌症协会
BACKGROUND. Ovarian carcinoma is the leading cause of death among all female reproductive malignancies. There are Substantial differences in age-adjusted incidence rates and survival rates between Caucasian women and African-American women. The objective of this study was to examine ethnic differences in survival after ovarian carcinoma in a population-based sample of women,METHODS. Thirteen thousand eighty-three patients (12285 Caucasian women and 798 African-American women) who were diagnosed with primary ovarian carcinoma from the population-based Surveillance, Epidemiology, and End Results (SEER) Program were used for analysis, Odds ratios were used to estimate the association between prognostic variables and ethnicity, Chi-square tests were used to determine the statistical significance of these associations (using two-sided P values). Univariable and multivariable Cox proportional hazards models were used to assess survival differences.RESULTS. African-American women were significantly younger at the time of diagnosis, were more likely to be single, and were less likely to undergo site specific surgery compared with Caucasian women. In addition, the crude median survival for African-American women was nearly 1 year less than for Caucasian women (22 months vs. 32 months, respectively; P < 0.0001), African-American women were at a 30% increased risk of death from any cause when adjusting for all other prognostic variables that differed between the two ethnic groups.CONCLUSIONS. African-American women who are diagnosed with ovarian carcinoma are at a significant increased risk of death from any cause compared with Caucasian women who are diagnosed with ovarian carcinoma. (C) 2002 American Cancer Society