GlyTouCan 1.0--The international glycan structure repository.
GlyTouCan 1.0--The international glycan structure repository.
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DOI：
10.1093/nar/gkv1041
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Narimatsu H
中科院分区：
文献类型：
--
作者：
Aoki-Kinoshita K;Agravat S;Aoki NP;Arpinar S;Cummings RD;Fujita A;Fujita N;Hart GM;Haslam SM;Kawasaki T;Matsubara M;Moreman KW;Okuda S;Pierce M;Ranzinger R;Shikanai T;Shinmachi D;Solovieva E;Suzuki Y;Tsuchiya S;Yamada I;York WS;Zaia J;Narimatsu H
聚糖被称为第三大类生物聚合物，仅次于DNA和蛋白质。它们覆盖许多细胞的表面，作为细胞的“面孔”，其他生物分子和病毒借此相互作用。然而，聚糖的结构与DNA和蛋白质有很大的不同，因为它们是支链的，而不是氨基酸或核苷酸的线性序列。因此，聚糖信息在数据库中的存储，更不用说它们的管理，一直是一个难题。当试图在不同的数据库之间进行整合时，这导致了许多重复的工作，使得有必要建立一个聚糖结构的国际储存库，其中为每个确定的聚糖结构分配唯一的登录号。因此，开发人员和糖生物学家的国际团队已经合作开发了这个称为GlyTouCan的储存库，并且可以在http：//glytoucan.org/上获得，以提供用于沉积聚糖结构、组成和拓扑结构的集中资源，并检索这些注册条目中的每一个的登录号。因此，这将使研究人员能够简单地通过登录号参考聚糖结构，而不是通过化学结构，这在过去一直是整合糖组学数据库的负担。
Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the ‘face’ of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.