Palladium-catalyzed sp3 C-H activation of simple alkyl groups:: Direct preparation of indoline derivatives from N-alkyl-2-bromoanilines
Palladium-catalyzed sp3 C-H activation of simple alkyl groups:: Direct preparation of indoline derivatives from N-alkyl-2-bromoanilines
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DOI：
10.1021/ol800425z
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发表时间：
2008-05-01
期刊：
影响因子：
5.2
通讯作者：
Ohno, Hiroaki
中科院分区：
文献类型：
--
作者：
Watanabe, Toshiaki;Oishi, Shinya;Ohno, Hiroaki
钯(0)催化的简单烷基的sp(3)C-H活化为从N-烷基-2-溴苯胺等简单前体合成各种吲哚提供了一种新的、方便的策略。这项研究表明，底物中的辅助部分，如吡啶或季碳，并不总是SP(3)C-H活化所必需的。
The sp(3) C-H activation of a simple alkyl group catalyzed by palladium(0) provides a novel and convenient strategy for the synthesis of various indolines from simple precursors, such as N-alkyl-2-bromoanilines. This study demonstrates that assisting moieties in the substrate such as a pyridine or quaternary carbon are not always necessary for sp(3) C-H activation.