The role of metabotropic glutamate receptors in addiction: Evidence from preclinical models
The role of metabotropic glutamate receptors in addiction: Evidence from preclinical models
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DOI：
10.1016/j.pbb.2011.03.015
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发表时间：
2012-02-01
影响因子：
3.6
通讯作者：
Lawrence, Andrew J.
中科院分区：
文献类型：
--
作者：
Duncan, Jhodie R.;Lawrence, Andrew J.
成瘾是一种慢性疾病，其特征是反复吸毒、戒断和复发。成瘾状态可能部分归因于药物诱导的中皮质边缘和皮质纹状体通路的神经适应。最近的焦点是异常谷氨酸传输的作用及其对这些系统的分层控制的贡献。这篇综述将扩展我们对临床前动物模型中最新进展的了解，这些进展提供了证据表明代谢型谷氨酸受体 (mGluR) 有助于与成瘾相关的神经适应，以及荷马蛋白在调节这些反应中的作用。我们将讨论最近发现的受体嵌合体，这为理解谷氨酸介导的行为机制的复杂性增加了一个额外的维度。最后，这篇综述介绍了一个与谷氨酸能反应相关的新领域，即 microRNA，它可能会成为指导我们未来了解如何最好地制定干预策略以防止成瘾行为的关键。 (C) 2011 Elsevier Inc. 保留所有权利。
Addiction is a chronic disorder characterised by repeated bouts of drug taking, abstinence and relapse. The addicted state may be in part due to drug-induced neuroadaptations in the mesocorticolimbic and corticostriatal pathways. Recently focus has been on the role of aberrant glutamate transmission and its contribution to the hierarchical control over these systems. This review will expand our current knowledge of the most recent advances that have been made in preclinical animal models that provide evidence that implicate metabotropic glutamate receptors (mGluRs) in contributing to the neuroadaptations pertinent to addiction, as well as the role of Homer proteins in regulating these responses. The recent discovery of receptor mosaics will be discussed which add an additional dimension to the complexity of understanding the mechanism of glutamate mediated behaviours. Finally this review introduces a new area related to glutamatergic responses, namely microRNAs, that may become pivotal in directing our future understanding of how to best target intervention strategies to prevent addictive behaviours. (C) 2011 Elsevier Inc. All rights reserved.