Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity
Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity
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DOI：
10.1016/j.atherosclerosis.2003.10.013
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发表时间：
2004-03-01
期刊：
影响因子：
5.3
通讯作者：
Toba, K
中科院分区：
文献类型：
--
作者：
Kobayashi, K;Akishita, M;Toba, K
肱动脉血流介导的扩张（FMD）、颈动脉内膜中层厚度（IMT）和脉搏波速度（PWV）已被证明是临床动脉粥样硬化的良好替代标志物。我们确定了这些测量值之间的相互关系，并检查了它们的组合是否具有临床意义。连续招募了 135 名受试者（79 名女性/56 名男性），其中包括 110 名具有动脉粥样硬化危险因素的患者，以及 33 名患有动脉粥样硬化疾病（如冠心病、中风或动脉硬化闭塞症）的患者。使用超声检查评估颈动脉的 IMT 和斑块形成以及肱动脉的 FMD。使用自动化设备（ABI/PWV，Colin）测量臂踝 PWV (baPWV)。年龄、FMD、IMT 和 PWV 彼此显着相关。多变量分析显示，除 FMD 外，其他参数之间均存在独立相关性，并且所有四个参数在受试者中均相互独立相关
Flow-mediated dilation (FMD) of the brachial artery, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) have been shown to be good surrogate markers of clinical atherosclerosis. We determined the interrelation between these measurements, and examined whether their combination would be of clinical significance. One hundred and thirty-five consecutive subjects (79 women/56 men) were enrolled, including 110 patients with risk factors for atherosclerosis, and 33 patients with atherosclerotic disease such as coronary heart disease, stroke or arteriosclerosis obliterans. IMT and plaque formation of the carotid artery and FMD of the brachial artery were assessed using ultrasonography. Brachial-ankle PWV (baPWV) was measured using an automated device (form ABI/PWV, Colin). Age, FMD, IMT and PWV were significantly correlated with each other. Multivariate analysis revealed an independent correlation between the parameters except for FMD, and all four parameters were independently correlated with each other in subjects