Selenomethionine: A review of its nutritional significance, metabolism and toxicity
Selenomethionine: A review of its nutritional significance, metabolism and toxicity
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DOI：
10.1093/jn/130.7.1653
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发表时间：
2000-07-01
影响因子：
4.2
通讯作者：
Schrauzer, GN
中科院分区：
文献类型：
--
作者：
Schrauzer, GN
虽然人类和动物营养中对硒的需求是公认的，但关于补充硒的适当形式的问题仍在争论中。理想情况下，硒应该以食物中自然存在的形式补充。由于硒代蛋氨酸（Se-met）的l -异构体是硒的主要天然食物形式，合成的L-Se-met或其强化食物来源，如酵母硒，是人类硒的适当补充形式；对于动物，DL-Se-met是可以接受的。摄入的硒要么被直接代谢为活性形式的硒，要么被储存在体内蛋白质中代替蛋氨酸。硒代谢与蛋白质周转密切相关。在营养范围内的恒定摄入量下，组织硒水平增加，直到建立稳定状态，防止积累到有毒水平。
Although the need for selenium in human and animal nutrition is well recognized, the question concerning the proper form of selenium for supplemental use is still being debated. Ideally, selenium should be supplemented in the form in which it occurs naturally in foods. Because the L-isomer of selenomethionine (Se-met) is a major natural food-form of selenium, synthetic L-Se-met or enriched food sources thereof such as selenium yeast are appropriate supplemental forms of Se for humans; for animals, DL-Se-met is acceptable. Ingested Se-met is either metabolized directly to reactive forms of selenium or stored in place of methionine in body proteins. Se-met metabolism is closely linked to protein turnover. At constant intakes in the nutritional range, tissue Se levels increase until a steady state is established, preventing the build-up to toxic levels.