North American Prodrome Longitudinal Study: A collaborative multisite approach to prodromal schizophrenia research
North American Prodrome Longitudinal Study: A collaborative multisite approach to prodromal schizophrenia research
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DOI：
10.1093/schbul/sbl075
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发表时间：
2007-05-01
影响因子：
6.6
通讯作者：
Heinssen, Robert
中科院分区：
文献类型：
--
作者：
Addington, Jean;Cadenhead, Kristin S.;Heinssen, Robert
本文介绍了北美前驱症状纵向研究（NAPLS）的基本原理、设计和初步结果，NAPLS是一项针对精神病早期阶段的协作性多地点调查。我们描述了8个独立构思的研究项目是如何在方法学上进行整合的，前驱综合征结构化访谈的诊断可靠性是如何在各站点实现的，以及888例风险和比较受试者的基线和随访数据是如何汇总的。数据描述的人口，学术/工作，和诊断特征的3个相关亚组：人在精神病的临床风险增加，寻求帮助的比较科目，和noupsychiatric控制。NAPLS数据集将用于探索一系列与前驱期精神病相关的问题，包括目前公认的诊断标准的描述性现象学，30个月内的转换率，精神病发作和功能障碍的预测因素，以及早期治疗对前驱期症状过程的影响。
This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and noupsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.