Association between bleomycin genotoxicity and non-constitutional risk factors for head and neck cancer.
Association between bleomycin genotoxicity and non-constitutional risk factors for head and neck cancer.
复制标题
博莱霉素基因毒性与头颈癌非宪法危险因素之间的关联。
DOI：
10.1016/0304-3835(93)90238-5
复制
发表时间：
1993
期刊：
影响因子：
9.7
通讯作者：
B. Braakhuis
中科院分区：
文献类型：
--
作者：
Jacqueline Cloos;I. Steen;Hans Joenje;Jeng Yo Ko;N. Vries;M. L. V. D. Sterre;Jos J. P. Nauta;Gordon B. Snow;B. Braakhuis
在器官和组织中的肿瘤患者中，植物血凝素刺激的淋巴细胞对博莱霉素性的敏感性增加，这些肿瘤与外部环境直接接触，如头和颈部的粘膜。对博莱霉素的敏感性可能反映了基因决定的对某些基因毒物的超敏反应，因此在致癌过程中可能是重要的。在这项研究中，博莱霉素的遗传毒性在40名无肿瘤病史的个体的培养淋巴细胞中的适用性进行了研究。没有观察到年龄的增加或众所周知的头颈部癌症风险因素与饮酒和吸烟的相关性。由于个体间的敏感性差异远远超过个体内的差异，我们的结果表明，博莱霉素裂解活性分数的升高可能识别对某些基因毒物具有结构性超敏反应的个体，并可能显示癌症易感性增加。
Sensitivity of phytohaemagglutinin-stimulated lymphocytes to bleomycin clastogenicity is increased in patients with tumours in organs and tissues that are in direct contact with the external environment, such as the mucosa of the head and neck [5]. Sensitivity to bleomycin may reflect a genetically determined hypersensitivity to certain genotoxicants and therefore may be important in the carcinogenic process. In this study the applicability of bleomycin genotoxicity was investigated in cultured lymphocytes of forty individuals without a tumour history. No correlations were observed with increasing age or the well-known head and neck cancer risk factors alcohol and tobacco consumption. Since inter-individual variation in sensitivity greatly exceeded intra-individual variation, our results suggest that an elevated bleomycin clastogenicity score may identify individuals who have a constitutional hypersensitivity towards certain genotoxicants and may show an increased cancer susceptibility.