Glycopeptide resistance in Enterococcus faecium from broilers and pigs following discontinued use of avoparcin
Glycopeptide resistance in Enterococcus faecium from broilers and pigs following discontinued use of avoparcin
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DOI：
10.1089/mdr.1999.5.53
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发表时间：
1999-03-01
影响因子：
2.6
通讯作者：
Wegener, HC
中科院分区：
文献类型：
--
作者：
Bager, F;Aarestrup, FM;Wegener, HC
1995年，丹麦停止使用糖肽生长促进剂阿伏帕星，原因是担心使用阿伏帕星后产生的耐万古霉素屎肠球菌可能通过食物转移给人类。本研究是对丹麦抗菌素耐药性持续监测（DANMAP）结果的分析，目的是确定禁令对分离自肉鸡和猪的屎肠球菌糖肽类耐药性发生的影响。从1995年底到1998年上半年，对糖肽具有耐药性的比例在统计上显示出高度显著的下降，而在猪身上，禁令似乎没有这种效果。一个可能的解释是，与猪群的连续生产相比，肉鸡行业通常使用全进全出生产。或者，结果表明，不同的结果可能是由于猪和肉鸡的不同共选择模式。在猪中，最常用的抗菌剂有利于糖肽耐药的E。而在肉鸡中最广泛使用的抗菌剂选择为糖肽敏感菌株。结果表明，减少抗生素耐药性的干预措施可能并不总是有效的，因此预防耐药性问题变得至关重要。
The use of the glycopeptide growth promoter avoparcin was discontinued in Denmark in 1995 following concerns that vancomycin-resistant Enterococcus faecium occurring as a result of its use could be transferred to humans via food. The present study is an analysis of results obtained by the continuous surveillance of an antimicrobial resistance in Denmark (DANMAP) with the aim of determining the effect of the ban on the occurrence of glycopeptide resistance among E, faecium isolated from broilers and pigs, Among isolates from broilers, the proportion that were resistant to glycopeptides has shown a statistically highly significant decline between the end of 1995 and the first half of 1998, whereas in pigs the ban appears to have had no such effect. One possible explanation is that the broiler industry generally uses all in-all out production compared with continuous production in pig herds. Alternatively, the results indicate that the different outcomes may result from different co-selection patterns in pigs and broilers. In pigs, the antimicrobials most commonly used favored co-selection of glycopeptide-resistant strains of E. faecium while in broilers the antimicrobials most widely used selected for glycopeptide-susceptible strains. The results show that intervention to reduce antimicrobial resistance may not always be effective and preventing resistance problems therefore becomes essential.