The effects of two HDR brachytherapy schedules in locally advanced cervical cancer treated with concurrent chemoradiation: a study from Chiang Mai, Thailand.
The effects of two HDR brachytherapy schedules in locally advanced cervical cancer treated with concurrent chemoradiation: a study from Chiang Mai, Thailand.
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两种 HDR 近距离放射治疗方案对同步放化疗的局部晚期宫颈癌的影响：泰国清迈的一项研究。
DOI：
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发表时间：
2012
影响因子：
2
通讯作者：
R. Galalae
中科院分区：
文献类型：
--
作者：
E. Tharavichitkul;Pitchayaponne Klunkin;V. Lorvidhaya;V. Sukthomya;Somvilai Chakrabhandu;Nantaka Pukanhaphan;I. Chitapanarux;R. Galalae
评估了同步放化疗中 HDR 近距离放射治疗不同方案的疗效。该研究比较了具有相同生物有效剂量 (BED) 的两种 HDR 近距离放射治疗方案对同步放化疗的局部晚期宫颈癌的有效性。该研究包括 377 名随机选择的 2004 年至 2006 年期间接受治疗的晚期宫颈癌患者。患者被分为第一组：7.2 Gy × 3 次剂量和第二组：6 Gy × 4 次剂量。中位随访时间为35个月，I组局部控制率、无病生存率和总生存率分别为80.8%、63.4%、98.8%，II组分别为86.7%、63.8%、97.3%。观察到的两种治疗方案在局部控制、无病生存、总生存和并发症发生率方面没有统计学意义。 I 组中有 7 名患者出现急性 2-4 级胃肠道毒性，II 组有 2 名患者出现急性 2-4 级胃肠道毒性。在GU毒性方面，I组中有3名患者和II组有3名患者出现了2-4级毒性。在晚期毒性中，I组中没有患者出现3-4级GU毒性，而II组中有两名患者出现3-4级GU毒性。在胃肠道毒性方面，第一组和第二组分别有 5 名和 6 名患者出现 3-4 级严重程度。两种 HDR 方案对于治疗局部晚期宫颈癌似乎都是安全有效的。
Efficacy of different schedules of HDR brachytherapy in concurrent chemoradiotherapy was evaluated. The study compared the effectiveness of the two HDR brachytherapy schedules which have the same Biological Effective Dose (BED) in locally advanced cervical carcinoma that was treated with concurrent chemoradiotherapy. Included in the study were 377 randomly selected patients with advanced carcinoma of the cervix uteri who were treated during the period 2004-2006. Patients were divided into Group I: 7.2 Gy × 3 fractions and Group II: 6 Gy × 4 fractions. With a median follow-up time of 35 months, local control, disease-free survival and overall survival rates were 80.8%, 63.4%, 98.8% in group I and 86.7%, 63.8%, 97.3% in group II, respectively. There was no statistical significance in terms of local control, disease-free survival, overall survival and complication rates between the two treatment schedules which could be observed. Seven patients in group I developed acute grade 2-4 GI toxicities and two patients in group II. In GU toxicities, there were three patients in group I and three patients in group II who developed grade 2-4 toxicities. In late toxicity, no patient developed grade 3-4 GU toxicities in group I while two patients developed grade 3-4 GU toxicities in group II. In GI toxicities, there were five and six patients in group I and group II, respectively, who developed grade 3-4 severity. Both HDR schedules seem to be safe and effective for the treatment of locally advanced cervical cancer.
影响因子：
45.3
作者：
Eifel, PJ;Winter, K;Mutch, DG
通讯作者：
Mutch, DG