Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring
Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring
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DOI：
10.1016/j.bbi.2013.12.003
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发表时间：
2014-03-01
影响因子：
15.1
通讯作者：
Salari, Ali-Akbar
中科院分区：
文献类型：
--
作者：
Babri, Shirin;Doosti, Mohammad-Hossein;Salari, Ali-Akbar
越来越多的证据表明，产前母体感染会增加晚年发生精神分裂症、自闭症、焦虑和抑郁等神经精神疾病的风险。实验研究表明，母体免疫激活对子代焦虑样行为和下丘脑-垂体-肾上腺(HPA)轴发育的影响是相互矛盾的。我们调查了怀孕期间母体免疫激活对怀孕小鼠及其后代焦虑和抑郁样行为的影响，以确定这些影响是否依赖于压力。NMRI和C57BL/6妊娠小鼠在妊娠第17天分别给予生理盐水和脂多糖治疗，然后测定妊娠小鼠及其子代的白细胞介素6(IL-6)和皮质酮(CUR)水平，以及焦虑或抑郁情绪。结果表明，母体炎症增加了NMRI怀孕小鼠的CUR水平和焦虑样行为，但对C57BL/6母鼠没有影响。我们的数据还表明，在高架正迷宫、高架零迷宫、悬尾试验和强迫游泳试验中，母体炎症分别增加了NMRI后代的焦虑和抑郁样行为水平，但在开阔场地和明暗盒子中没有。此外，我们没有发现成年C57BL/6后代的焦虑和抑郁行为有任何显著变化。我们的发现表明，产前母体免疫激活可以以一种紧张和任务依赖的方式改变后代的HPA轴活动、焦虑和抑郁样行为，还需要进一步的全面研究来证明这些发现之间的因果关系，并验证它们与人类神经精神疾病的相关性。(C)2013 Elsevier Inc.保留所有权利。
There is converging evidence that prenatal maternal infection can increase the risk of occurrence of neuropsychiatric disorders like schizophrenia, autism, anxiety and depression in later life. Experimental studies have shown conflicting effects of prenatal maternal immune activation on anxiety-like behavior and hypothalamic-pituitary-adrenal (HPA) axis development in offspring. We investigated the effects of maternal immune activation during pregnancy on anxiety- and depression-like behaviors in pregnant mice and their offspring to determine whether these effects are dependent on strain. NMRI and C57BL/6 pregnant mice were treated with either saline or lipopolysaccharide on gestational day 17 and then interleukin (IL)-6 and corticosterone (CUR) levels; anxiety or depression in the pregnant mice and their offspring were evaluated. The results indicate that maternal inflammation increased the levels of CUR and anxiety-like behavior in NMRI pregnant mice, but not in C57BL/6 dams. Our data also demonstrate that maternal inflammation elevated the levels of anxiety-and depression-like behaviors in NMRI offspring on the elevated plus-maze, elevated zero-maze, tail suspension test and forced swimming test respectively, but not in the open field and light-dark box. In addition, we did not find any significant change in anxiety- and depression-like behaviors of adult C57BL/6 offspring. Our findings suggest that prenatal maternal immune activation can alter the HPA axis activity, anxiety- and depression-like behaviors in a strain- and task-dependent manner in offspring and further comprehensive studies are needed to prove the causal relationship between the findings found here and to validate their relevance to neuropsychiatric disorders in humans. (C) 2013 Elsevier Inc. All rights reserved.