Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease
Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease
复制标题
在炎症性肠病的治疗中，次黄嘌呤鸟嘌呤磷酸核糖基转移酶活性与 6-硫鸟嘌呤核苷酸浓度和硫嘌呤诱导的白细胞减少症相关。
DOI：
10.1002/ibd.21676
复制
发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Huang, Ming
中科院分区：
文献类型：
--
作者：
Ding, Liang;Zhang, Fang-bin;Huang, Ming
背景：硫嘌呤类药物广泛用于炎症性肠病(IBD)的治疗。硫代嘌呤S甲基转移酶(TPMT)的多态与硫嘌呤的代谢和不良事件的发生密切相关。其他硫代谢酶的作用不太为人所知。本研究探讨TPMT和次黄嘌呤鸟嘌呤磷酸核糖基转移酶(HPRT)活性对IBD患者6-硫代鸟嘌呤核苷酸(6-TGNs)浓度和硫代嘌呤所致白细胞减少的影响。
Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well known. This study investigated the effects of TPMT and hypoxanthine guanine phosphoribosyltransferase (HPRT) activities on 6-thioguanine nucleotides (6-TGNs) concentrations and thiopurine-induced leukopenia in patients with IBD.