The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.
The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.
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下丘脑腹内侧核：全身血糖稳态的看门狗。
DOI：
10.1186/s13578-022-00799-2
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发表时间：
2022-05-26
影响因子：
7.5
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Tu, Longlong;Fukuda, Makoto;Tong, Qingchun;Xu, Yong
关键词：
大脑，特别是下丘脑腹内侧核（VMH），长期以来一直被认为参与葡萄糖感知和全身葡萄糖稳态。然而，大脑如何检测和响应循环葡萄糖水平的变化以及大脑-身体协调控制葡萄糖稳态仍然没有完全理解。在这篇综述中，我们讨论了越来越多的证据表明，大脑在葡萄糖稳态，特别是在低血糖和糖尿病的背景下。除了神经元，我们强调的潜在作用所发挥的非神经元细胞，以及细胞外基质在下丘脑在全身葡萄糖稳态。此外，我们回顾了葡萄糖敏感神经元感知周围葡萄糖水平波动的离子机制。我们还介绍了VMH中异质神经元对葡萄糖感知和全身葡萄糖稳态的重要意义，其中也涉及性别差异。同时，也发现了研究空白，这需要进一步的机制研究在未来。
The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is still not fully understood how the brain detects and responds to the changes in the circulating glucose levels, as well as brain-body coordinated control of glucose homeostasis. In this review, we address the growing evidence implicating the brain in glucose homeostasis, especially in the contexts of hypoglycemia and diabetes. In addition to neurons, we emphasize the potential roles played by non-neuronal cells, as well as extracellular matrix in the hypothalamus in whole-body glucose homeostasis. Further, we review the ionic mechanisms by which glucose-sensing neurons sense fluctuations of ambient glucose levels. We also introduce the significant implications of heterogeneous neurons in the VMH upon glucose sensing and whole-body glucose homeostasis, in which sex difference is also addressed. Meanwhile, research gaps have also been identified, which necessities further mechanistic studies in future.
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影响因子：
3.7
作者：
Maekawa F;Fujiwara K;Toriya M;Maejima Y;Nishio T;Toyoda Y;Nohara K;Yashiro T;Yada T
通讯作者：
Yada T
影响因子：
56.9
作者：
Akbari, Parsa;Gilani, Ankit;Sosina, Olukayode;Kosmicki, Jack A.;Khrimian, Lori;Fang, Yi-Ya;Persaud, Trikaldarshi;Garcia, Victor;Sun, Dylan;Li, Alexander;Mbatchou, Joelle;Locke, Adam E.;Benner, Christian;Verweij, Niek;Lin, Nan;Hossain, Sakib;Agostinucci, Kevin;Pascale, Jonathan, V;Dirice, Ercument;Dunn, Michael;Kraus, William E.;Shah, Svati H.;Chen, Yii-Der, I;Rotter, Jerome, I;Rader, Daniel J.;Melander, Olle;Still, Christopher D.;Mirshahi, Tooraj;Carey, David J.;Berumen-Campos, Jaime;Kuri-Morales, Pablo;Alegre-Diaz, Jesus;Torres, Jason M.;Emberson, Jonathan R.;Collins, Rory;Balasubramanian, Suganthi;Hawes, Alicia;Jones, Marcus;Zambrowicz, Brian;Murphy, Andrew J.;Paulding, Charles;Coppola, Giovanni;Overton, John D.;Reid, Jeffrey G.;Shuldiner, Alan R.;Cantor, Michael;Kang, Hyun M.;Abecasis, Goncalo R.;Karalis, Katia;Economides, Aris N.;Marchini, Jonathan;Yancopoulos, George D.;Sleeman, Mark W.;Altarejos, Judith;Della Gatta, Giusy;Tapia-Conyer, Roberto;Schwartzman, Michal L.;Baras, Aris;Ferreira, Manuel A. R.;Lotta, Luca A.
通讯作者：
Lotta, Luca A.
影响因子：
8.2
作者：
Alonge KM;D'Alessio DA;Schwartz MW
通讯作者：
Schwartz MW
影响因子：
7.7
作者：
Chan, O;Zhu, WL;Sherwin, RS
通讯作者：
Sherwin, RS
影响因子：
4.8
作者：
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通讯作者：
Butler, Andrew A.