Self-assembly of naturally occurring stigmasterol in liquids yielding a fibrillar network and gel.
Self-assembly of naturally occurring stigmasterol in liquids yielding a fibrillar network and gel.
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作者：
豆甾醇是一种天然存在的6-6-6-5单羟基植物甾醇，从印度药用植物Roscoea purpurea（俗称Kakoli）的叶子中提取。在继续我们对天然存在的萜类化合物的自组装性质的研究中，本文中，我们报告了这种植物甾醇在不同有机液体中的第一次自组装性质。该分子在有机液体中自组装，在大多数研究的液体中产生超分子凝胶，通过形成纳米至微米直径的纤维和带状结构。通过扫描电子显微镜、透射电子显微镜、原子力显微镜、光学显微镜、FTIR和X射线衍射研究对自组装体进行了表征，结果表明自组装体具有纤维状网络和带状结构。基于分子模拟研究、X射线衍射数据和FTIR研究，提出了豆甾醇的自组装模型。流变学研究表明，凝胶具有较高的机械强度。荧光团如罗丹明B、羧基荧光素（包括抗癌药物阿霉素）可以装载在凝胶中。此外，还证明了包括药物的负载荧光团从凝胶相释放到水性介质中。从Roscoea purpurea叶中提取的豆甾醇在液体中自发自组装，产生纤维状网络和凝胶。
Stigmasterol, a naturally occurring 6-6-6-5 monohydroxy phytosterol, was extracted from the leaves of Indian medicinal plant Roscoea purpurea, commonly known as Kakoli. In continuation of our studies on the self-assembly properties of naturally occurring terpenoids, herein, we report the first self-assembly properties of this phytosterol in different organic liquids. The molecule self-assembled in organic liquids yielding supramolecular gels in most of the liquids studied via the formation of fibers and belt-like architechtures of nano-to micrometer diameter. Characterization of the self-assemblies carried out by using scanning electron microscopy, transmission electron microscopy, atomic force microscopy, optical microscopy, FTIR and X-ray diffraction studies indicated fibrillar network and belt-like structures. A model for the self-assembly of stigmasterol has been proposed based on molecular modeling studies, X-ray diffraction data and FTIR studies. Rheology studies indicated that the gels were of high mechanical strength. Fluorophores such as rhodamine B, carboxy fluorescein including the anticancer drug doxorubicin could be loaded in the gels. Moreover, release of the loaded fluorophores including the drug has also been demonstrated from the gel phase into aqueous medium. Stigmasterol extracted from the leaves of Roscoea purpurea spontaneously self-assembled in liquids yielding a fibrillar network and gel.
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影响因子：
9.8
作者：
Baccile, Niki;Nassif, Nadine;Babonneau, Florence
通讯作者：
Babonneau, Florence
DOI：
10.1073/pnas.90.24.11628
发表时间：
1993-12-15
影响因子：
11.1
作者：
COREY, EJ;MATSUDA, SPT;BARTEL, B
通讯作者：
BARTEL, B
影响因子：
6.7
作者：
Bag, Braja Gopal;Dash, Shib Shankar
通讯作者：
Dash, Shib Shankar
影响因子：
15
作者：
Ajayaghosh, A;George, SJ
通讯作者：
George, SJ
影响因子：
9.8
作者：
Delample, Mathieu;Jerome, Francois;Douliez, Jean-Paul
通讯作者：
Douliez, Jean-Paul