MECHANISM OF ENTEROVIRAL INACTIVATION BY OZONE
MECHANISM OF ENTEROVIRAL INACTIVATION BY OZONE
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DOI：
10.1128/aem.41.3.718-723.1981
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发表时间：
1981-01-01
影响因子：
4.4
通讯作者：
CHIAN, ESK
中科院分区：
文献类型：
--
作者：
ROY, D;WONG, PKY;CHIAN, ESK
以脊髓灰质炎病毒1型（Mahoney）为模型病毒，探讨了臭氧灭活肠道病毒的机理。臭氧改变了脊髓灰质炎病毒1型病毒蛋白质外壳中4条多肽链中的2条。蛋白质外壳的改变并没有显著损害病毒吸附[宿主细胞]或改变病毒颗粒的完整性。通过速度沉降分析证明了暴露于臭氧后对病毒RNA的损伤。对病毒核酸的破坏显然是臭氧灭活脊髓灰质炎病毒1的主要原因。[有关臭氧灭活肠道病毒机制的信息将有助于开发数学模型，以预测臭氧消毒过程在水和废水处理中灭活病毒的性能。
The mechanism of enteroviral inactivation by ozone was investigated with poliovirus 1 (Mahoney) as the model virus. Ozone altered 2 of the 4 polypeptide chains present in the viral protein coat of poliovirus 1. The alteration of the protein coat did not significantly impair virus adsorption [to host cells] or alter the integrity of the virus particle. Damage to the viral RNA after exposure to ozone was demonstrated by velocity sedimentation analysis. The damage to the viral nucleic acid is apparently the major cause of poliovirus 1 inactivation by ozone. [Information regarding the mechanism of inactivation of enteroviruses by ozone would be useful in developing mathematical models to predict the performance of the ozone disinfection process as applied to the inactivation of viruses in water and wastewater treatment.].