Thiourea-catalyzed enantioselective hydrophosphonylation of imines:: Practical access to enantiomerically enriched α-amino phosphonic acids
Thiourea-catalyzed enantioselective hydrophosphonylation of imines:: Practical access to enantiomerically enriched α-amino phosphonic acids
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DOI：
10.1021/ja0494398
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发表时间：
2004-04-07
影响因子：
15
通讯作者：
Jacobsen, EN
中科院分区：
文献类型：
--
作者：
Joly, GD;Jacobsen, EN
手性硫脲1b催化多种N-苄基亚胺的高对映选择性氢膦酰化反应。氢膦酰化产物容易通过氢解脱保护，从而提供以高度对映体富集形式的游离α-氨基膦酸。
Chiral thiourea1bcatalyzes the highly enantioselective hydrophosphonylation of a wide range ofN-benzyl imines. The hydrophosphonylation products are readily deprotected by hydrogenolysis, providing access to free α-amino phosphonic acids in highly enantioenriched form.