Medication use in breast cancer survivors compared to midlife women.
Medication use in breast cancer survivors compared to midlife women.
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与中年女性相比，乳腺癌幸存者的药物使用情况。
DOI：
10.1007/s00520-013-1727-5
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Carpenter,JanetS
中科院分区：
文献类型：
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作者：
Otte,JulieL;Skaar,ToddC;Wu,Jingwei;Yu,Menggang;Ryker,Kristin;Burns,DebraS;Carpenter,JanetS
目的：许多乳腺癌幸存者（BCS）由于与所治疗的癌症和其他非癌症合并症相关的健康问题而服用多种药物。然而，没有发表的，大规模的描述性评价药物使用的BCS相比，中年妇女。本研究的目的是（1）比较BCS和中年妇女之间的处方药和非处方药的数量和类型没有癌症和（2）评估可能的药物相互作用，通过评估细胞色素P450亚型的药物（电感器和抑制剂）在这两个group.MethodsA横断面，描述性，比较设计。基线数据从98 BCS和138中年妇女没有癌症进行了分析，从行为干预试验更年期symptoms.ResultsBCS采取显着更多的处方药和更大的各种不同类型的药物分类（p< 0.05）后，控制组的差异（种族，非癌症共病的条件下，婚姻状况，收入和吸烟）的人口统计学。24名妇女服用至少一种药物被认为是一种细胞色素P450亚型（CYP450）抑制剂或诱导剂能够临床药物相互作用，在CYP450抑制剂或诱导剂组之间没有差异。目前还不清楚处方药是由一个医疗保健提供者还是几个提供者管理。临床意义是监测各种处方药，非处方药和补充剂之间可能的相互作用。行为和生物医学研究的意义是，临床研究需要仔细评估和帐户多药物uses.Relevance的studyThe研究结果是相关的研究和实践肿瘤学和全科医生。评估药物信息的重要性提供了有关癌症幸存者症状管理的信息。此外，药物的潜在相互作用影响各种治疗的疗效，并影响患者的依从性。
PurposeMany breast cancer survivors (BCS) take multiple medications for health problems associated with the treated cancer and other noncancer comorbidities. However, there is no published, large-scale descriptive evaluation of medication use in BCS compared to midlife women. The purpose of this study was (1) to compare the number and types of prescription medications and over-the-counter medications between BCS and midlife women without cancer and (2) to assess possible drug–drug interactions by evaluating the cytochrome P450 isoform properties of medications (inductors and inhibitors) in both groups.MethodsA cross-sectional, descriptive, comparative design was used. Baseline data from 98 BCS and 138 midlife women without cancer was analyzed from a behavioral intervention trial for menopausal symptoms.ResultsBCS were taking significantly more prescription medications and a larger variety of different types of medication classifications (p< 0.05) after controlling for group differences (race, noncancer comorbid conditions, marital status, income, and smoking) in demographics. Twenty-four women were taking at least one medication considered to be a cytochrome P450 isoforms (CYP) inhibitor or inducer capable of clinical drug–drug interactions with no differences in CYP inhibitors or inducers found between groups.ConclusionBCS are taking a vast array of medications during survivorship. It is unclear if prescription medications are managed by a single healthcare provider or several providers. Clinical implications are to monitor for possible interactions among the various prescription medications, over-the-counter medications, and supplements. Implications for behavioral and biomedical research are that clinical studies need to carefully assess and account for multiple medication uses.Relevance of the studyThe findings of this study are relevant to research and practice for both oncology and general practitioners. The importance of assessing medication information provides information about symptom management in individuals surviving cancer. In addition, the potential interaction of drugs impacts efficacy of various treatments and impacts compliance by patients.