Remodeling phenotype of macrophages in steroid-induced osteonecrosis: switching from M1 to M2 polarization-猫眼课题宝

DOI：

10.14800/macrophage.1007

发表时间：

2015-09

期刊：

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Xinghuo Wu;Cao Yang;Xiaobo Feng;Yong Gao;Shuhua Yang;Zengwu Shao;Z. Ye

骨坏死是骨科常见病，是世界性的医学难题，亟待攻克。在过去的几十年里，骨坏死的病理生理机制已经取得了重大进展，但其病因仍然复杂且不清楚。激素性骨坏死的发病机制有多种学说，包括血栓、脂肪、异常红细胞、氮等引起的微循环栓塞和骨髓细胞肥大。其中，在激素性骨坏死的各种学说中，脂肪代谢紊乱学说是公认的。然而，股骨头坏死的发病机制十分复杂，很难用单一的理论来解释。巨噬细胞的极化参与了许多重要的病理生理过程，如坏死和再生。我们的假设是，M1极化的巨噬细胞在激素诱导的股骨头坏死（SANFH）的早期和中期表现出破坏性，而M2极化的巨噬细胞在晚期表现出保护性，它们在SANFH的发展中起重要作用。该假说有助于解释激素性骨坏死的发病机制，值得进一步研究。

Osteonecrosis, a common orthopaedic disease, is a worldwide medical problem need to be conquered. Over the past decades, major advances have occurred in the pathophysiological mechanisms of osteonecrosis, however, its etiology is still complex and not clear. A number of different theories have been developed to explain the pathogenic mechanisms of steroid-induced osteonecrosis, including Microcirculation embolism and bone marrow cell hypertrophy induced by thrombus, fat, abnormal red blood cells, nitrogen, etc.. Among them, theory of fat metabolism disorder is generally recognized among the kinds of theories of steroid-induced osteonecrosis. However, the pathogenesis of femoral head osteonecrosis very complicated, and it’s difficult to be explained using the single theory. The polarization of Macrophages are involved in many important pathophysiologic processes, such as necrosis and regeneration. Our hypothesis is that M1-polarised Macrophages appear to be disruptive in the early and middle stage of steroid-induced osteonecrosis of femoral head (SANFH), while M2-polarised Macrophages appear to be protective in the late stage, which play an important role in developing SANFH. Our hypothesis could help to explain the pathogenic mechanism of steroid-induced osteonecrosis, and deserves further studies.

Remodeling phenotype of macrophages in steroid-induced osteonecrosis: switching from M1 to M2 polarization

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