High-density lipoprotein cholesterol and risk of stroke in Japanese men and women - The Oyabe study
High-density lipoprotein cholesterol and risk of stroke in Japanese men and women - The Oyabe study
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DOI：
10.1161/01.str.0000060869.34009.38
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发表时间：
2003-04-01
期刊：
影响因子：
8.3
通讯作者：
Nakagawa, H
中科院分区：
文献类型：
--
作者：
Soyama, Y;Miura, K;Nakagawa, H
背景和目的：在亚洲人和女性中，血清高密度脂蛋白胆固醇（HDL-C）与卒中风险呈负相关的证据很少。这项调查的目的是在一项长期队列研究中，对中风发生率高于西方国家的日本男性和女性进行研究。方法：在日本农村地区进行了一项前瞻性队列研究，涉及4989名参与者（1523名男性，3466名女性），基线年龄为35至79岁，随访时间约为10年。终点包括所有脑卒中发生率和缺血性脑卒中发生率。结果：随访期间，132名参与者发生中风，其中81例为缺血性中风。低HDL-C人群中所有脑卒中的年龄调整发病率(
Background and Purpose-Evidence of an inverse relationship between serum high-density lipoprotein cholesterol (HDL-C) and the risk of stroke is sparse in Asians and in women. The purpose of this investigation was to examine the relationship in a long-term cohort study of Japanese men and women among whom stroke occurrence is higher than in Western countries.Methods-A prospective cohort study was performed involving 4989 participants (1523 men, 3466 women) 35 to 79 years of age at baseline with approximate to10 years of follow-up in a rural area of Japan. End points included all stroke incidence and ischemic stroke incidence.Results-During follow-up, 132 participants developed stroke, including 81 ischemic stroke cases. Age-adjusted incidence rates per 10 000 person-years for all stroke in subjects with low HDL-C (