Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells
Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells
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DOI：
10.1016/j.bbrc.2008.06.121
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发表时间：
2008-09-12
影响因子：
3.1
通讯作者：
Amri, Ez-Zoubir
中科院分区：
文献类型：
--
作者：
Chiellini, Chiara;Grenningloh, Gabriele;Amri, Ez-Zoubir
Stathmin-like 2(STMN2)蛋白。Stathmin家族的一种神经元蛋白，作为细胞骨架调节的关键元件，被认为参与了微管调节网络。在此，我们描述了在人脂肪组织间充质干细胞(hMADS细胞)和骨髓间充质干细胞(HBMS细胞)成骨过程中，STMN2在mRNA和蛋白水平上的表达增加，而在脂肪形成过程中它的表达水平下降到检测不到的水平。STMN2蛋白定位于高尔基体和胞质间。在成骨细胞中，它的表达似乎受到神经生长因子、地塞米松或RhoA激酶抑制剂Y-27632的调节，这些都是已知的成骨效应因子。因此，STMN2是一种新的成骨和成骨细胞标志物，可能在调节脂肪细胞/成骨细胞平衡中发挥作用。(C)2008 Elsevier Inc.保留所有权利。
Stathmin-like 2 (STMN2) protein. a neuronal protein of the stathmin family, has been implicated in the microtubule regulatory network as a crucial element of cytoskeletal regulation. Herein, we describe that STMN2 expression increases at both mRNA and protein levels during osteogenesis of human mesenchymal stem cells derived from adipose tissue (hMADS cells) and bone marrow (hBMS cells), whereas it decreases to undetectable levels during adipogenesis. STMN2 protein is localized in both Golgi and cytosolic compartments. Its expression appears modulated in osteoblasts by nerve growth factor, dexamethasone or RhoA kinase inhibitor Y-27632 which are known effectors of osteogenesis. Thus STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. (C) 2008 Elsevier Inc. All rights reserved.