The mammalian TRPC cation channels
The mammalian TRPC cation channels
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DOI：
10.1016/j.bbamcr.2004.08.015
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发表时间：
2004-12-06
影响因子：
5.1
通讯作者：
Putney, JW
中科院分区：
文献类型：
--
作者：
Vazquez, G;Wedel, BJ;Putney, JW
瞬时受体电位-经典(TRPC)通道是瞬时受体电位(Trp)的哺乳动物同系物，Trp是参与果蝇磷脂酶C调节的光感受器激活机制的一种钙离子通透通道。这七个哺乳动物TRPC构成了一个通道家族，它们被认为在各种细胞类型中既可以作为存储操作的通道，也可以作为第二信使操作的通道。TRPC通道与其他亲缘关系较远的通道家族一起组成了更大的Trp通道超家族。本文综述了近年来有关广泛存在的TRPC阳离子通道的结构、调控和功能的研究进展。爱思唯尔出版公司(Elsevier B.V.)
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca2+-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the Structure, regulation and function of the apparently ubiquitous TRPC cation channels. Published by Elsevier B.V.