Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998
Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998
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DOI：
10.3201/eid0802.010165
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发表时间：
2002-02-01
影响因子：
11.8
通讯作者：
Perkins, BA
中科院分区：
文献类型：
--
作者：
Hajjeh, RA;Relman, D;Perkins, BA
1995年5月1日至1998年12月31日，在美国新发感染计划的四个地点（人口770万）对可能由感染原因造成的不明原因死亡和危重疾病（UNEX）进行了人群监测，以确定该综合征的发病率、流行病学特征和病因。病例被定义为住院、先前健康、年龄在 1 至 49 岁之间、具有感染特征但在常规检测后未发现原因的死亡或危重疾病。总共发现了 137 例病例（发病率为每年每 10 万人中 0.5 例）。患者中位年龄为 20 岁，其中 72 例 (53%) 为女性，112 例 (82±10) 例为白人，41 例 (30%) 死亡。最常见的临床表现是神经系统（29%）、呼吸系统（27%）和心脏系统（21%）。 34例确诊感染原因（占122例临床标本的28%）； 23 例 (68%) 通过参考血清学检测进行诊断，11 例 (32%) 通过基于聚合酶链反应的方法进行诊断。 UNEX 网络模型将提高美国的诊断能力和对新出现感染的准备。
Population-based surveillance for unexplained death and critical illness possibly due to infectious causes (UNEX) was conducted in four U.S. Emerging Infections Program sites (population 7.7 million) from May 1, 1995, to December 31, 1998, to define the incidence, epidemiologic features, and etiology of this syndrome. A case was defined as death or critical illness in a hospitalized, previously healthy person, 1 to 49 years of age, with infection hallmarks but no cause identified after routine testing. A total of 137 cases were identified (incidence rate 0.5 per 100,000 per year). Patients' median age was 20 years, 72 (53%) were female, 112 (82 10) were white, and 41 (30%) died. The most common clinical presentations were neurologic (29%), respiratory (27 Io), and cardiac (21%). Infectious causes were identified for 34 cases (28% of the 122 cases with clinical specimens); 23 (68%) were diagnosed by reference serologic tests, and 11 (32%) by polymerase chain reaction-based methods. The UNEX network model would improve U.S. diagnostic capacities and preparedness for emerging infections.