Acute postnatal regulation of pyruvate carboxylase activity by compartmentation of mitochondrial adenine nucleotides.
Acute postnatal regulation of pyruvate carboxylase activity by compartmentation of mitochondrial adenine nucleotides.
复制标题
通过线粒体腺嘌呤核苷酸的区室对丙酮酸羧化酶活性进行急性产后调节。
DOI：
10.1016/0304-4165(81)90080-5
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Rulfs,J
中科院分区：
文献类型：
--
作者：
Aprille,JR;Yaswen,P;Rulfs,J
在大鼠肝脏中，线粒体基质的总腺嘌呤核苷酸含量在出生后几小时内增加3-4倍。这为丙酮酸羧化酶的急性产后调节提供了一种机制，丙酮酸羧化酶位于基质室中，需要ATP作为底物。丙酮酸羧化酶活性的突然增加被认为是导致新生大鼠的致炎率迅速增加4-5倍的原因。
The total adenine nucleotide content of the mitochondrial matrix increases 3–4-fold within a few hours of birth in rat liver. This provides a mechanism for the acute postnatal regulation of pyruvate carboxylase, which is located in the matrix compartment and which requires ATP as a substrate. The sudden increase in pyruvate carboxylase activity is proposed to account for a rapid 4–5-fold increase in the gluconeogenic rate of the newborn rat.