Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene
Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene
复制标题
TMPRSS2基因中富含GC的外显子区域的分子内G-四链体-发夹环结构竞争
DOI：
10.1039/d1cc05523b
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
and K. Kawauchi
中科院分区：
文献类型：
--
作者：
W. Sugimoto;N. Kinoshita;M. Nakata;T. Ohyama;H. Tateishi-Karimata;T. Nishikata;N. Sugimoto;D. Miyoshi;and K. Kawauchi
我们确定了蛋白酶基因中富含胞嘧啶的区域与富含鸟嘌呤的区域相邻。一个典型的GC丰富的序列来自TMPRSS 2基因之间的G-四链体和发夹环的结构竞争，这种竞争显着影响转录效率。这些结果表明邻近序列对富含鸟嘌呤序列的基因表达的影响。
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the TMPRSS2 gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results suggest an impact of neighboring sequences on the gene expression of guanine-rich sequences.