Phenotyping Stroke in Sub-Saharan Africa: Stroke Investigative Research and Education Network (SIREN) Phenomics Protocol.
Phenotyping Stroke in Sub-Saharan Africa: Stroke Investigative Research and Education Network (SIREN) Phenomics Protocol.
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DOI：
10.1159/000437372
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发表时间：
2015
影响因子：
5.7
通讯作者：
SIREN as part of the H3Africa Consortium
中科院分区：
文献类型：
--
作者：
Akpalu A;Sarfo FS;Ovbiagele B;Akinyemi R;Gebregziabher M;Obiako R;Owolabi L;Sagoe K;Jenkins C;Arulogun O;Adamu S;Appiah LT;Adadey MA;Agyekum F;Quansah JA;Mensah YB;Adeoye AM;Singh A;Tosin AO;Ohifemen O;Sani AA;Tabi-Ajayi E;Phillip IO;Isah SY;Tabari NA;Mande A;Agunloye AM;Ogbole GI;Akinyemi JO;Akpa OM;Laryea R;Melikam SE;Adinku D;Uvere E;Burkett NS;Adekunle GF;Kehinde SI;Azuh PC;Dambatta AH;Ishaq NA;Arnett D;Tiwari HK;Lackland D;Owolabi M;SIREN as part of the H3Africa Consortium
作为第二大死亡原因和成人发病残疾的主要原因，中风是一个主要的公共卫生问题，尤其与撒哈拉以南非洲 (SSA) 相关，该地区的中风死亡率占全球中风死亡率的近 80%，预计未来几十年中中风负担将增加。然而，SSA 中风的传统和新兴危险因素尚未得到很好的描述，因此限制了遏制其毁灭性死亡的努力。中风调查研究和教育网络（SIREN）项目旨在全面评估 SSA 中风（及其亚型）的关键环境和基因组危险因素，同时建设脑研究的表型组学、生物库、基因组学、生物统计学和生物信息学能力。 SIREN 是一项跨国、多中心、以医院和社区为基础的研究，涉及从加纳和尼日利亚 8 个地点招募的 3000 名病例和 3000 名对照者。病例是发病 10 天内首次中风的住院患者，将对这些患者进行神经血管成像。所有病例的病因学和地形学中风亚型都将被记录。对照组将是医院和社区的参与者，其性别、种族和年龄（± 5 岁）与病例相匹配。将收集有关已知和拟议的新出现的中风危险因素的信息。 SIREN 是迄今为止非洲最大规模的中风研究。预计它将揭示中风的表型特征和危险因素，并最终为战略干预措施提供证据基础，以减轻次大陆日益增长的中风负担。
As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in sub-Saharan Africa (SSA) where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, the traditional and emerging risk factors for stroke in SSA have not been well characterized thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics and bioinformatics for brain research. SIREN is a transnational, multicentre, hospital and community-based study involving 3000 cases and 3000 controls recruited from 8 sites in Ghana and Nigeria. Cases will be hospital-based patients with first stroke within 10 days of onset in whom neurovascular imaging will be performed. Etiological and topographical stroke subtypes will be documented for all cases. Controls will be hospital- and community-based participants, matched for gender, ethnicity and age (± 5 years) to cases. Information will be collected on known and proposed emerging risk factors for stroke. SIREN is the largest study of stroke in Africa to date. It is anticipated that it will shed light on the phenotypic characteristics and risk factors of stroke and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of stroke on the sub-continent.