It's Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control.
It's Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control.
复制标题
DOI：
10.3389/fgene.2022.931220
复制
发表时间：
2022
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞在空间上组织它们的分子组分，以进行基本的生物过程并指导适当的发育。RNA在细胞内的空间组织可以促进基因表达调控，也可以由基因表达调控引起。最近的研究已经证明了RNA空间模式和翻译调控之间的多种关联。生物分子凝聚物中的一种模式化，即区室化，一直受到特别关注。通常，与细胞质生物分子缩合物（如胚芽颗粒、应激颗粒和P体）相关的转录物与低翻译状态相关。然而，最近的研究已经确定了新的生物分子缩合物与不同的角色与主动翻译。这篇综述概述了RNA区室化在各种缩合物中发生与抑制或活性翻译状态，突出了最近的研究结果在良好的缩合物，并探讨了新的缩合物的行为。
Cells spatially organize their molecular components to carry out fundamental biological processes and guide proper development. The spatial organization of RNA within the cell can both promote and result from gene expression regulatory control. Recent studies have demonstrated diverse associations between RNA spatial patterning and translation regulatory control. One form of patterning, compartmentalization in biomolecular condensates, has been of particular interest. Generally, transcripts associated with cytoplasmic biomolecular condensates—such as germ granules, stress granules, and P-bodies—are linked with low translational status. However, recent studies have identified new biomolecular condensates with diverse roles associated with active translation. This review outlines RNA compartmentalization in various condensates that occur in association with repressed or active translational states, highlights recent findings in well-studied condensates, and explores novel condensate behaviors.