Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage
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DOI：
10.1038/s41467-020-16851-z
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发表时间：
2020-06-22
影响因子：
16.6
通讯作者：
Wang, Yongjun
中科院分区：
文献类型：
--
作者：
Chen, Jinman;Wang, Linmei;Wang, Yongjun
脑脊液(CSF)中的外渗红细胞在蛛网膜下腔出血(SAH)的发病机制中起重要作用。据报道，脑膜淋巴管将大分子和免疫细胞从脑脊液中排出，进入颈部淋巴结(CLN)。然而，SAH后脑膜淋巴管是否参与清除脑脊液中渗出的红细胞仍不清楚。本研究显示SAH后CLN淋巴管和脑膜淋巴管中聚集的红细胞数量明显增多。在SAH小鼠模型中，当脑膜淋巴管耗尽时，CLN中的红细胞聚集程度显著降低，同时相关的神经炎症和神经功能障碍显著加剧。此外，在SAH期间，淋巴流量增加，但没有明显的淋巴管生成和淋巴管扩张。综上所述，这项工作证明了SAH后脑膜淋巴管将外溢的红细胞从脑脊液排入CLN，同时提示调节这种引流可能提供减轻SAH严重程度的治疗方法。脑脊液(CSF)中的外渗红细胞参与了蛛网膜下腔出血(SAH)的发病。在这里，作者表明，脑膜淋巴管排出渗出的红细胞，阻断这种引流会加重SAH的严重程度。
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH remains unclear. Here we show that a markedly higher number of erythrocytes are accumulated in the lymphatics of CLNs and meningeal lymphatics after SAH. When the meningeal lymphatics are depleted in a mouse model of SAH, the degree of erythrocyte aggregation in CLNs is significantly lower, while the associated neuroinflammation and the neurologic deficits are dramatically exacerbated. In addition, during SAH lymph flow is increased but without significant lymphangiogenesis and lymphangiectasia. Taken together, this work demonstrates that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity. Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH severity.