Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
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DOI：
10.1002/ijc.22682
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发表时间：
2007-07-15
影响因子：
6.4
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
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作者：
Kuriki, Kiyonori;Hirose, Kaoru;Tajima, Kazuo
饮食中摄入富含n-3高度不饱和脂肪酸（HUFA）的鱼类，如二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），已被提议降低癌症风险。然而，与实验室研究的结果相反，流行病学研究证明对乳腺癌的保护作用是模棱两可的。在本病例对照研究中，我们研究了乳腺癌风险与红细胞膜中脂肪酸成分之间的关系，作为这些摄入量的生物标志物。从103例乳腺癌病例和309例非癌症对照（年龄和季节匹配）中收集了饮食信息和血液样本，并使用加速溶剂提取和气液色谱法测量了红细胞脂肪酸。膳食中n-3 HUFA的摄入量与风险呈负相关（最高与最低三分位数，比值比（OR），0.51; 95%置信区间（CI），0.27-0.98; p（趋势）< 0.05），但与饱和脂肪酸（SFA）和肉类的摄入量无关。此外，风险与EPA的红细胞成分呈负相关，（OR，0.27; 95% CI，0.14-0.53; p（趋势）< 0.0001），DHA（OR，0.06; 95% CI，0.02-0.16; p（趋势）< 0.0001）和n-3 HUFA（OR，0.11; 95%CI，0.05-0.24; p（趋势）< 0.0001），与SFA呈正相关（OR，12.29; 95%CI，4.94-30.57; p（趋势）< 0.0001）和SFA/n-3 HUFA比值（OR，14.65; 95%CI，5.67-37.82; p（趋势）< 0.0001）。总之，我们表明，来自鱼类摄入的特定脂肪酸的红细胞成分，作为生物标志物，与乳腺癌的风险降低有关，但需要进一步研究来调查与病因学相关的机制。(C)2007 Wiley-Liss，Inc.
Dietary intake of fish rich in n-3 highly unsaturated fatty acids (HUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been proposed to decrease cancer risk. In contrast to results from laboratory studies, however, protective effects for breast cancer have proved equivocal in epidemiological studies. In the present case-control study, we examined associations between breast cancer risk and fatty acid compositions in erythrocyte membranes as biomarkers for those intakes. Dietary information and blood samples were collected from 103 incident breast cancer cases and 309 non-cancer controls (matched by age and season) and erythrocyte fatty acids were measured using accelerated solvent extraction and gas-liquid chromatography. Dietary intake of n-3 HUFAs demonstrated a negative association with risk (the highest to the lowest tertile, odds ratio (OR), 0.51; 95% confidence interval (CI), 0.27-0.98; p(trend) < 0.05), but there was no association with those of saturated fatty acids (SFAs) and meat. Moreover, risk was inversely associated with erythrocyte compositions of EPA (OR, 0.27; 95% CI, 0.14-0.53; p(trend) < 0.0001), DHA (OR, 0.06; 95% CI, 0.02-0.16; p(trend) < 0.0001) and n-3 HUFAs (OR, 0.11; 95% CI, 0.05-0.24; p(trend) < 0.0001), and positively with that of SFAs (OR, 12.29; 95% CI, 4.94-30.57; p(trend) < 0.0001) and the ratio of SFAs/n-3 HUFAs (OR, 14.65; 95% CI, 5.67-37.82; p(trend) < 0.0001). In conclusion, we showed that erythrocyte compositions of specific fatty acids derived from fish intake, as bionnarkers, are associated with lower risk of breast cancer, but further studies are needed to investigate mechanisms linked to the etiology. (C) 2007 Wiley-Liss, Inc.