Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population.
Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population.
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DOI：
10.2188/jea.je20110039
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发表时间：
2012
影响因子：
4.7
通讯作者：
Kishi R
中科院分区：
文献类型：
--
作者：
Yila TA;Sasaki S;Miyashita C;Braimoh TS;Kashino I;Kobayashi S;Okada E;Baba T;Yoshioka E;Minakami H;Endo T;Sengoku K;Kishi R
细胞内叶酸止血依赖于5，10-亚甲基四氢叶酸还原酶（MTHFR）基因。由于5，10-MTHFR 677 TT纯合性和吸烟与低叶酸状态相关，我们检验了以下假设：携带5，10-MTHFR C677 T或A1298 C多态性的母亲吸烟与其后代出生体重较低独立相关。我们评估了1784对来自北海道环境与儿童健康研究的出生队列的日本本土母婴对。数据（人口统计学信息，医院出生记录和生物标本）提取自2003年2月至2006年3月期间的招募。采用荧光免疫分析法测定孕妇血清叶酸水平，采用TaqMan等位基因识别法进行5，10-MTHFR C677 T/A1298 C多态性基因分型。叶酸缺乏（<6.8nmol/L）的患病率为0.3%。5，10-MTHFR 677 CT基因型与平均婴儿出生体重增加36.40 g（95%CI：2.60至70.30，P = 0.035）以及不吸烟男婴中增加90.70 g（95%CI：6.00至175.50，P = 0.036）独立相关。677 TT纯合子被动吸烟者的女婴体重轻了99.00 g（95%CI：-190.26至-7.56，P = 0.034）。携带5，10-MTHFR 1298 AA纯合性的吸烟者的后代出生体重低107.00 g（95% CI：-180.00 to-33.90，P = 0.004）。结果表明，在这个人群中，母亲5，10-MTHFR C677 T多态性，而不是5，10-MTHFR A1298 C变异，与婴儿出生体重的改善独立相关，特别是在非吸烟者中。然而，5，10-MTHFR 1298 AA可能与叶酸损伤有关，并可能与烟草烟雾相互作用，进一步降低出生体重。
Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Because 5,10-MTHFR 677TT homozygosity and tobacco smoking are associated with low folate status, we tested the hypothesis that smoking in mothers with 5,10-MTHFR C677T or A1298C polymorphisms would be independently associated with lower birth weight among their offspring. We assessed 1784 native Japanese mother-child pairs drawn from the ongoing birth cohort of The Hokkaido Study on Environment and Children’s Health. Data (demographic information, hospital birth records, and biological specimens) were extracted from recruitments that took place during the period from February 2003 to March 2006. Maternal serum folate were assayed by chemiluminescent immunoassay, and genotyping of 5,10-MTHFR C677T/A1298C polymorphisms was done using a TaqMan allelic discrimination assay. The prevalence of folate deficiency (<6.8 nmol/L) was 0.3%. The 5,10-MTHFR 677CT genotype was independently associated with an increase of 36.40 g (95% CI: 2.60 to 70.30, P = 0.035) in mean infant birth weight and an increase of 90.70 g (95% CI: 6.00 to 175.50, P = 0.036) among male infants of nonsmokers. Female infants of 677TT homozygous passive smokers were 99.00 g (95% CI: −190.26 to −7.56, P = 0.034) lighter. The birth weight of the offspring of smokers with 5,10-MTHFR 1298AA homozygosity was lower by 107.00 g (95% CI: −180.00 to −33.90, P = 0.004). The results suggest that, in this population, maternal 5,10-MTHFR C677T polymorphism, but not the 5,10-MTHFR A1298C variant, is independently associated with improvement in infant birth weight, especially among nonsmokers. However, 5,10-MTHFR 1298AA might be associated with folate impairment and could interact with tobacco smoke to further decrease birth weight.
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DOI：
10.1073/pnas.062066299
发表时间：
2002-04-16
影响因子：
11.1
作者：
Friso, S;Choi, SW;Selhub, J
通讯作者：
Selhub, J
影响因子：
3.6
作者：
Chango, A;Fillon-Emery, N;Nicolas, JP
通讯作者：
Nicolas, JP
影响因子：
6.1
作者：
Foka, ZJ;Lambropoulos, AF;Kotsis, A
通讯作者：
Kotsis, A
DOI：
10.1016/s0301-2115(00)00540-6
发表时间：
2001-08-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Gebhardt, GS;Scholtz, CL;Odendaal, HJ
通讯作者：
Odendaal, HJ
影响因子：
4.4
作者：
Courtemanche, C;Elson-Schwab, I;Ames, BN
通讯作者：
Ames, BN