Radiation Carcinogenesis in Animal Models: Part 1
Radiation Carcinogenesis in Animal Models: Part 1
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动物模型中的辐射致癌：第 1 部分
DOI：
10.11323/jjmp.41.3_143
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
福士 政広
中科院分区：
文献类型：
--
作者：
高畠 賢;井上 一雅;福士 政広
对原子弹幸存者和接受放射治疗的患者的流行病学研究表明，接触电离辐射 (IR) 会增加患癌症的风险。尽管辐射致癌作用在每个器官中都会发生变化，但红外线的致癌作用已有充分记录。众所周知，乳腺对辐射诱发的癌症高度敏感。我们之前报道过（i）青春期前和青春期后IR诱导的大鼠乳腺癌中DNA甲基化模式的差异；（ii）胎次对青春期前和青春期后IR之间大鼠乳腺癌发生的影响不同。在这篇综述中，我们总结了我们的辐射研究以及与啮齿动物模型中的其他辐射研究相关的研究。
Exposure to ionizing radiation (IR) increases the risk of cancers, as epidemiology studies of atomic bomb survivors and patients who have received radiotherapy show. The carcinogenic effects of IR are well-documented, although the effects of radiation carcinogenesis change in each organ. The mammary gland is known to be highly susceptible to radiation-induced cancer. We have previously reported that (i) differential DNA methylation patterns in rat mammary carcinomas induced by pre-and post-pubertal IR;(ii) the effect of parity on rat mammary carcinogenesis varies between pre-and post-pubertal IR. In this review, we summarize our radiation researches as well as related with other radiation researches in rodent models.